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11β-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD.
Webster JM, Waaijenberg K, van de Worp WRPH, Kelders MCJM, Lambrichts S, Martin C, Verhaegen F, Van der Heyden B, Smith C, Lavery GG, Schols AMWJ, Hardy RS, Langen RCJ. Webster JM, et al. Among authors: lavery gg. Am J Physiol Lung Cell Mol Physiol. 2023 Apr 1;324(4):L400-L412. doi: 10.1152/ajplung.00009.2022. Epub 2023 Feb 21. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 36807882 Free PMC article.
Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells.
Ahasan MM, Hardy R, Jones C, Kaur K, Nanus D, Juarez M, Morgan SA, Hassan-Smith Z, Bénézech C, Caamaño JH, Hewison M, Lavery G, Rabbitt EH, Clark AR, Filer A, Buckley CD, Raza K, Stewart PM, Cooper MS. Ahasan MM, et al. Arthritis Rheum. 2012 Jul;64(7):2404-13. doi: 10.1002/art.34414. Arthritis Rheum. 2012. PMID: 22294469 Free PMC article.
Therapeutic glucocorticoids prevent bone loss but drive muscle wasting when administered in chronic polyarthritis.
Fenton CG, Webster JM, Martin CS, Fareed S, Wehmeyer C, Mackie H, Jones R, Seabright AP, Lewis JW, Lai YC, Goodyear CS, Jones SW, Cooper MS, Lavery GG, Langen R, Raza K, Hardy RS. Fenton CG, et al. Among authors: lavery gg. Arthritis Res Ther. 2019 Aug 1;21(1):182. doi: 10.1186/s13075-019-1962-3. Arthritis Res Ther. 2019. PMID: 31370858 Free PMC article.
11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension.
Hardy RS, Botfield H, Markey K, Mitchell JL, Alimajstorovic Z, Westgate CSJ, Sagmeister M, Fairclough RJ, Ottridge RS, Yiangou A, Storbeck KH, Taylor AE, Gilligan LC, Arlt W, Stewart PM, Tomlinson JW, Mollan SP, Lavery GG, Sinclair AJ. Hardy RS, et al. Among authors: lavery gg. J Clin Endocrinol Metab. 2021 Jan 1;106(1):174-187. doi: 10.1210/clinem/dgaa766. J Clin Endocrinol Metab. 2021. PMID: 33098644 Free PMC article. Clinical Trial.
162 results