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164 results

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Page 1
11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial.
Othonos N, Pofi R, Arvaniti A, White S, Bonaventura I, Nikolaou N, Moolla A, Marjot T, Stimson RH, van Beek AP, van Faassen M, Isidori AM, Bateman E, Sadler R, Karpe F, Stewart PM, Webster C, Duffy J, Eastell R, Gossiel F, Cornfield T, Hodson L, Jane Escott K, Whittaker A, Kirik U, Coleman RL, Scott CAB, Milton JE, Agbaje O, Holman RR, Tomlinson JW. Othonos N, et al. Among authors: nikolaou n. Nat Commun. 2023 Feb 23;14(1):1025. doi: 10.1038/s41467-023-36541-w. Nat Commun. 2023. PMID: 36823106 Free PMC article. Clinical Trial.
Co-administration of 5α-reductase Inhibitors Worsens the Adverse Metabolic Effects of Prescribed Glucocorticoids.
Othonos N, Marjot T, Woods C, Hazlehurst JM, Nikolaou N, Pofi R, White S, Bonaventura I, Webster C, Duffy J, Cornfield T, Moolla A, Isidori AM, Hodson L, Tomlinson JW. Othonos N, et al. Among authors: nikolaou n. J Clin Endocrinol Metab. 2020 Sep 1;105(9):e3316-28. doi: 10.1210/clinem/dgaa408. J Clin Endocrinol Metab. 2020. PMID: 32594135 Free PMC article. Clinical Trial.
Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo.
Nikolaou N, Arvaniti A, Appanna N, Sharp A, Hughes BA, Digweed D, Whitaker MJ, Ross R, Arlt W, Penning TM, Morris K, George S, Keevil BG, Hodson L, Gathercole LL, Tomlinson JW. Nikolaou N, et al. J Endocrinol. 2020 May;245(2):207-218. doi: 10.1530/JOE-19-0473. J Endocrinol. 2020. PMID: 32106090 Free PMC article.
Acute intermittent hypoxia drives hepatic de novo lipogenesis in humans and rodents.
Hazlehurst JM, Lim TR, Charlton C, Miller JJ, Gathercole LL, Cornfield T, Nikolaou N, Harris SE, Moolla A, Othonos N, Heather LC, Marjot T, Tyler DJ, Carr C, Hodson L, McKeating J, Tomlinson JW. Hazlehurst JM, et al. Among authors: nikolaou n. Metabol Open. 2022 Mar 14;14:100177. doi: 10.1016/j.metop.2022.100177. eCollection 2022 Jun. Metabol Open. 2022. PMID: 35313531 Free PMC article.
Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man.
Hazlehurst JM, Oprescu AI, Nikolaou N, Di Guida R, Grinbergs AE, Davies NP, Flintham RB, Armstrong MJ, Taylor AE, Hughes BA, Yu J, Hodson L, Dunn WB, Tomlinson JW. Hazlehurst JM, et al. Among authors: nikolaou n. J Clin Endocrinol Metab. 2016 Jan;101(1):103-13. doi: 10.1210/jc.2015-2928. Epub 2015 Nov 17. J Clin Endocrinol Metab. 2016. PMID: 26574953 Free PMC article. Clinical Trial.
AKR1D1 knockout mice develop a sex-dependent metabolic phenotype.
Gathercole LL, Nikolaou N, Harris SE, Arvaniti A, Poolman TM, Hazlehurst JM, Kratschmar DV, Todorčević M, Moolla A, Dempster N, Pink RC, Saikali MF, Bentley L, Penning TM, Ohlsson C, Cummins CL, Poutanen M, Odermatt A, Cox RD, Tomlinson JW. Gathercole LL, et al. Among authors: nikolaou n. J Endocrinol. 2022 Apr 13;253(3):97-113. doi: 10.1530/JOE-21-0280. J Endocrinol. 2022. PMID: 35318963 Free PMC article.
AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease.
Nikolaou N, Gathercole LL, Marchand L, Althari S, Dempster NJ, Green CJ, van de Bunt M, McNeil C, Arvaniti A, Hughes BA, Sgromo B, Gillies RS, Marschall HU, Penning TM, Ryan J, Arlt W, Hodson L, Tomlinson JW. Nikolaou N, et al. Metabolism. 2019 Oct;99:67-80. doi: 10.1016/j.metabol.2019.153947. Epub 2019 Jul 19. Metabolism. 2019. PMID: 31330134 Free PMC article.
164 results