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Drug Development.
Zhao HT, Chen XQ, Das U, Zuo X, Ford BT, Kordasiewicz HB, Mobley WC. Zhao HT, et al. Among authors: kordasiewicz hb. Alzheimers Dement. 2024 Dec;20 Suppl 6(Suppl 6):e092628. doi: 10.1002/alz.092628. Alzheimers Dement. 2024. PMID: 39782431 Free PMC article.
Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding.
Mathews EW, Coffey SR, Gärtner A, Belgrad J, Bragg RM, O'Reilly D, Cantle JP, McHugh C, Summers A, Fentz J, Schwagarus T, Cornelius A, Lingos I, Burch Z, Kovalenko M, Andrew MA, Frank Bennett C, Kordasiewicz HB, Marchionini DM, Wilkinson H, Vogt TF, Pinto RM, Khvorova A, Howland D, Wheeler VC, Carroll JB. Mathews EW, et al. Among authors: kordasiewicz hb. bioRxiv [Preprint]. 2024 Nov 4:2024.11.04.619693. doi: 10.1101/2024.11.04.619693. bioRxiv. 2024. PMID: 39574582 Free PMC article. Preprint.
A single-cell map of antisense oligonucleotide activity in the brain.
Mortberg MA, Gentile JE, Nadaf NM, Vanderburg C, Simmons S, Dubinsky D, Slamin A, Maldonado S, Petersen CL, Jones N, Kordasiewicz HB, Zhao HT, Vallabh SM, Minikel EV. Mortberg MA, et al. Among authors: kordasiewicz hb. Nucleic Acids Res. 2023 Aug 11;51(14):7109-7124. doi: 10.1093/nar/gkad371. Nucleic Acids Res. 2023. PMID: 37188501 Free PMC article.
A single-cell map of antisense oligonucleotide activity in the brain.
Mortberg MA, Gentile JE, Nadaf N, Vanderburg C, Simmons S, Dubinsky D, Slamin A, Maldonado S, Petersen CL, Jones N, Kordasiewicz HB, Zhao HT, Vallabh SM, Minikel EV. Mortberg MA, et al. Among authors: kordasiewicz hb. bioRxiv [Preprint]. 2023 Feb 14:2023.02.14.528473. doi: 10.1101/2023.02.14.528473. bioRxiv. 2023. Update in: Nucleic Acids Res. 2023 Aug 11;51(14):7109-7124. doi: 10.1093/nar/gkad371 PMID: 36824749 Free PMC article. Updated. Preprint.
RNA-targeted therapy corrects neuronal deficits in PACS1 syndrome mice.
Villar-Pazos S, Thomas L, Yang Y, Chen K, Lyles JB, Deitch BJ, Ochaba J, Ling K, Powers B, Gingras S, Kordasiewicz HB, Grubisha MJ, Huang YH, Thomas G. Villar-Pazos S, et al. Among authors: kordasiewicz hb. Res Sq [Preprint]. 2023 Jan 27:rs.3.rs-2440581. doi: 10.21203/rs.3.rs-2440581/v1. Res Sq. 2023. Update in: Nat Commun. 2023 Oct 17;14(1):6547. doi: 10.1038/s41467-023-42176-8 PMID: 36747781 Free PMC article. Updated. Preprint.
Regional variability and genotypic and pharmacodynamic effects on PrP concentration in the CNS.
Mortberg MA, Zhao HT, Reidenbach AG, Gentile JE, Kuhn E, O'Moore J, Dooley PM, Connors TR, Mazur C, Allen SW, Trombetta BA, McManus A, Moore MR, Liu J, Cabin DE, Kordasiewicz HB, Mathews J, Arnold SE, Vallabh SM, Minikel EV. Mortberg MA, et al. Among authors: kordasiewicz hb. JCI Insight. 2022 Mar 22;7(6):e156532. doi: 10.1172/jci.insight.156532. JCI Insight. 2022. PMID: 35133987 Free PMC article.
Erratum: LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model.
Zhao HT, John N, Delic V, Ikeda-Lee K, Kim A, Weihofen A, Swayze EE, Kordasiewicz HB, West AB, Volpicelli-Daley LA. Zhao HT, et al. Among authors: kordasiewicz hb. Mol Ther Nucleic Acids. 2021 May 29;24:1051-1053. doi: 10.1016/j.omtn.2021.05.013. eCollection 2021 Jun 4. Mol Ther Nucleic Acids. 2021. PMID: 34141459 Free PMC article.
40 results