Wang K - Search Results

1

Discovery of pterostilbene analogs as novel NLRP3 inflammasome inhibitors for potential treatment of DSS-induced colitis in mice.

Ruan B, Rong M, Ming Z, Wang K, Liu X, Deng L, Zhang X, Xu K, Shi C, Gao T, Liu X, Chen L. Ruan B, et al. Among authors: wang k. Bioorg Chem. 2023 Apr;133:106429. doi: 10.1016/j.bioorg.2023.106429. Epub 2023 Feb 18. Bioorg Chem. 2023. PMID: 36841048

2

Discovery and Development of Inflammatory Inhibitors from 2-Phenylchromonone (Flavone) Scaffolds.

Xu C, Fang MY, Wang K, Liu J, Tai GP, Zhang ZT, Ruan BF. Xu C, et al. Among authors: wang k. Curr Top Med Chem. 2020;20(28):2578-2598. doi: 10.2174/1568026620666200924115611. Curr Top Med Chem. 2020. PMID: 32972343 Review.

3

Design and synthesis of pterostilbene derivatives bearing triazole moiety that might treat DSS-induced colitis in mice through modulation of NF-κB/MAPK signaling pathways.

Chen L, Wang K, Wang L, Wang W, Wang L, Wang W, Li J, Liu X, Wang M, Ruan B. Chen L, et al. Among authors: wang w, wang l, wang k, wang m. Eur J Med Chem. 2024 Jan 5;263:115949. doi: 10.1016/j.ejmech.2023.115949. Epub 2023 Nov 17. Eur J Med Chem. 2024. PMID: 37989058

4

Design, synthesis, in vitro and in vivo biological evaluation of pterostilbene derivatives for anti-inflammation therapy.

Chen L, Wang K, Liu X, Wang L, Zou H, Hu S, Zhou L, Li R, Cao S, Ruan B, Cui Q. Chen L, et al. Among authors: wang l, wang k. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2315227. doi: 10.1080/14756366.2024.2315227. Epub 2024 Feb 29. J Enzyme Inhib Med Chem. 2024. PMID: 38421003 Free PMC article.

5

Discovery of selective covalent cathepsin K inhibitors containing novel 4-cyanopyrimidine warhead based on quantum chemical calculations and binding mode analysis.

Jia Y, Wang K, Wang H, Zhang B, Yang K, Zhang Z, Dong H, Wang J. Jia Y, et al. Among authors: wang h, wang k, wang j. Bioorg Med Chem. 2022 Nov 15;74:117053. doi: 10.1016/j.bmc.2022.117053. Epub 2022 Oct 9. Bioorg Med Chem. 2022. PMID: 36270112

6

Discovery of novel sulfonamide chromone-oxime derivatives as potent indoleamine 2,3-dioxygenase 1 inhibitors.

Wang K, Song LH, Liang QL, Zhang Y, Ma XL, Wang Q, Zhang HY, Jiang CN, Wei JH, Huang RZ. Wang K, et al. Among authors: wang q. Eur J Med Chem. 2023 Jun 5;254:115349. doi: 10.1016/j.ejmech.2023.115349. Epub 2023 Apr 11. Eur J Med Chem. 2023. PMID: 37060754

7

Discovery of a novel class of reversible monoacylglycerol lipase inhibitors for potential treatment of depression.

Hao Q, Shi J, Zhang Z, Yang G, Zhi Y, Wang K, Ma D, Fu S, Dong H, Zhi Z, Zhang W, Li T, Wang J. Hao Q, et al. Among authors: wang k, wang j. Eur J Med Chem. 2024 Mar 15;268:116285. doi: 10.1016/j.ejmech.2024.116285. Epub 2024 Feb 26. Eur J Med Chem. 2024. PMID: 38428273

8

Discovery of a Novel ASM Direct Inhibitor with a 1,5-Diphenyl-pyrazole Scaffold and Its Antidepressant Mechanism of Action.

Shi S, Ma D, Guo X, Chen Y, Yu J, Hu X, Wang X, Li T, Wang K, Zhi Y, Yang G, Lin L, Hao Q, Yang Y, Yang K, Wang J. Shi S, et al. Among authors: wang x, wang k, wang j. J Med Chem. 2024 Jun 27;67(12):10350-10373. doi: 10.1021/acs.jmedchem.4c00831. Epub 2024 Jun 18. J Med Chem. 2024. PMID: 38888140

9

Synthesis and structure-activity relationships of N - (3 - (1H-imidazol-2-yl) phenyl) - 3-phenylpropionamide derivatives as a novel class of covalent inhibitors of p97/VCP ATPase.

Wang K, Chen L, Dai X, Ye Z, Zhou C, Zhang CJ, Feng Z. Wang K, et al. Eur J Med Chem. 2023 Feb 15;248:115094. doi: 10.1016/j.ejmech.2023.115094. Epub 2023 Jan 6. Eur J Med Chem. 2023. PMID: 36634454

10

Synthesis and Biological Evaluation of Novel 2-Amino-1,4-Naphthoquinone Amide-Oxime Derivatives as Potent IDO1/STAT3 Dual Inhibitors with Prospective Antitumor Effects.

Huang RZ, Liang QL, Jing XT, Wang K, Zhang HY, Wang HS, Ma XL, Wei JH, Zhang Y. Huang RZ, et al. Among authors: wang hs, wang k. Molecules. 2023 Aug 19;28(16):6135. doi: 10.3390/molecules28166135. Molecules. 2023. PMID: 37630387 Free PMC article.

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