Takeuchi K - Search Results

1

Functional molecular evolution of a GTP sensing kinase: PI5P4Kβ.

Takeuchi K, Senda M, Ikeda Y, Okuwaki K, Fukuzawa K, Nakagawa S, Sasaki M, Sasaki AT, Senda T. Takeuchi K, et al. FEBS J. 2023 Sep;290(18):4419-4428. doi: 10.1111/febs.16763. Epub 2023 Mar 10. FEBS J. 2023. PMID: 36856076 Free PMC article.

2

A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation.

Davis MI, Sasaki AT, Shen M, Emerling BM, Thorne N, Michael S, Pragani R, Boxer M, Sumita K, Takeuchi K, Auld DS, Li Z, Cantley LC, Simeonov A. Davis MI, et al. Among authors: takeuchi k. PLoS One. 2013;8(1):e54127. doi: 10.1371/journal.pone.0054127. Epub 2013 Jan 10. PLoS One. 2013. PMID: 23326584 Free PMC article.

3

Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis.

Sumita K, Yoshino H, Sasaki M, Majd N, Kahoud ER, Takahashi H, Takeuchi K, Kuroda T, Lee S, Charest PG, Takeda K, Asara JM, Firtel RA, Anastasiou D, Sasaki AT. Sumita K, et al. Among authors: takeuchi k. J Biol Chem. 2014 Feb 14;289(7):3950-9. doi: 10.1074/jbc.M113.531178. Epub 2013 Dec 13. J Biol Chem. 2014. PMID: 24338482 Free PMC article.

4

The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.

Sumita K, Lo YH, Takeuchi K, Senda M, Kofuji S, Ikeda Y, Terakawa J, Sasaki M, Yoshino H, Majd N, Zheng Y, Kahoud ER, Yokota T, Emerling BM, Asara JM, Ishida T, Locasale JW, Daikoku T, Anastasiou D, Senda T, Sasaki AT. Sumita K, et al. Among authors: takeuchi k. Mol Cell. 2016 Jan 21;61(2):187-98. doi: 10.1016/j.molcel.2015.12.011. Epub 2016 Jan 7. Mol Cell. 2016. PMID: 26774281 Free PMC article.

5

Structural reverse genetics study of the PI5P4Kβ-nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells.

Takeuchi K, Senda M, Lo YH, Kofuji S, Ikeda Y, Sasaki AT, Senda T. Takeuchi K, et al. FEBS J. 2016 Oct;283(19):3556-3562. doi: 10.1111/febs.13739. FEBS J. 2016. PMID: 27090388 Free PMC article. Review.

6

The crystal structure of a new O-demethylase from Sphingobium sp. strain SYK-6.

Harada A, Kamimura N, Takeuchi K, Yu HY, Masai E, Senda T. Harada A, et al. Among authors: takeuchi k. FEBS J. 2017 Jun;284(12):1855-1867. doi: 10.1111/febs.14085. Epub 2017 May 11. FEBS J. 2017. PMID: 28429420 Free article.

7

Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story.

Naffouje R, Grover P, Yu H, Sendilnathan A, Wolfe K, Majd N, Smith EP, Takeuchi K, Senda T, Kofuji S, Sasaki AT. Naffouje R, et al. Among authors: takeuchi k. Cancers (Basel). 2019 Sep 11;11(9):1346. doi: 10.3390/cancers11091346. Cancers (Basel). 2019. PMID: 31514446 Free PMC article. Review.

8

Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification.

Osaka N, Hirota Y, Ito D, Ikeda Y, Kamata R, Fujii Y, Chirasani VR, Campbell SL, Takeuchi K, Senda T, Sasaki AT. Osaka N, et al. Among authors: takeuchi k. Front Mol Biosci. 2021 Jul 8;8:707439. doi: 10.3389/fmolb.2021.707439. eCollection 2021. Front Mol Biosci. 2021. PMID: 34307463 Free PMC article. Review.

9

3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents.

Konno S, Kobayashi K, Senda M, Funai Y, Seki Y, Tamai I, Schäkel L, Sakata K, Pillaiyar T, Taguchi A, Taniguchi A, Gütschow M, Müller CE, Takeuchi K, Hirohama M, Kawaguchi A, Kojima M, Senda T, Shirasaka Y, Kamitani W, Hayashi Y. Konno S, et al. Among authors: takeuchi k. J Med Chem. 2022 Feb 24;65(4):2926-2939. doi: 10.1021/acs.jmedchem.1c00665. Epub 2021 Jul 27. J Med Chem. 2022. PMID: 34313428

10

The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off between activity and specificity.

Takeuchi K, Ikeda Y, Senda M, Harada A, Okuwaki K, Fukuzawa K, Nakagawa S, Yu HY, Nagase L, Imai M, Sasaki M, Lo YH, Ito D, Osaka N, Fujii Y, Sasaki AT, Senda T. Takeuchi K, et al. Structure. 2022 Jun 2;30(6):886-899.e4. doi: 10.1016/j.str.2022.04.004. Epub 2022 May 2. Structure. 2022. PMID: 35504278 Free PMC article.

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