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MicroRNA 483-3p overexpression unleashes invasive growth of metastatic colorectal cancer via NDRG1 downregulation and ensuing activation of the ERBB3/AKT axis.
Candiello E, Reato G, Verginelli F, Gambardella G, D Ambrosio A, Calandra N, Orzan F, Iuliano A, Albano R, Sassi F, Luraghi P, Comoglio PM, Bertotti A, Trusolino L, Boccaccio C. Candiello E, et al. Among authors: orzan f. Mol Oncol. 2023 Jul;17(7):1280-1301. doi: 10.1002/1878-0261.13408. Epub 2023 Mar 19. Mol Oncol. 2023. PMID: 36862005 Free PMC article.
The MET oncogene is a functional marker of a glioblastoma stem cell subtype.
De Bacco F, Casanova E, Medico E, Pellegatta S, Orzan F, Albano R, Luraghi P, Reato G, D'Ambrosio A, Porrati P, Patanè M, Maderna E, Pollo B, Comoglio PM, Finocchiaro G, Boccaccio C. De Bacco F, et al. Among authors: orzan f. Cancer Res. 2012 Sep 1;72(17):4537-50. doi: 10.1158/0008-5472.CAN-11-3490. Epub 2012 Jun 26. Cancer Res. 2012. PMID: 22738909 Free article.
MET inhibition overcomes radiation resistance of glioblastoma stem-like cells.
De Bacco F, D'Ambrosio A, Casanova E, Orzan F, Neggia R, Albano R, Verginelli F, Cominelli M, Poliani PL, Luraghi P, Reato G, Pellegatta S, Finocchiaro G, Perera T, Garibaldi E, Gabriele P, Comoglio PM, Boccaccio C. De Bacco F, et al. Among authors: orzan f. EMBO Mol Med. 2016 May 2;8(5):550-68. doi: 10.15252/emmm.201505890. Print 2016 May. EMBO Mol Med. 2016. PMID: 27138567 Free PMC article.
Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer.
Isella C, Brundu F, Bellomo SE, Galimi F, Zanella E, Porporato R, Petti C, Fiori A, Orzan F, Senetta R, Boccaccio C, Ficarra E, Marchionni L, Trusolino L, Medico E, Bertotti A. Isella C, et al. Among authors: orzan f. Nat Commun. 2017 May 31;8:15107. doi: 10.1038/ncomms15107. Nat Commun. 2017. PMID: 28561063 Free PMC article.
A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem-Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy.
Luraghi P, Bigatto V, Cipriano E, Reato G, Orzan F, Sassi F, De Bacco F, Isella C, Bellomo SE, Medico E, Comoglio PM, Bertotti A, Trusolino L, Boccaccio C. Luraghi P, et al. Among authors: orzan f. Clin Cancer Res. 2018 Feb 15;24(4):807-820. doi: 10.1158/1078-0432.CCR-17-2151. Epub 2017 Oct 3. Clin Cancer Res. 2018. PMID: 28974546 Free article.
A simplified integrated molecular and immunohistochemistry-based algorithm allows high accuracy prediction of glioblastoma transcriptional subtypes.
Orzan F, Pagani F, Cominelli M, Triggiani L, Calza S, De Bacco F, Medicina D, Balzarini P, Panciani PP, Liserre R, Buglione M, Fontanella MM, Medico E, Galli R, Isella C, Boccaccio C, Poliani PL; on behalf of the Neuro-Oncology group of Spedali Civili of Brescia. Orzan F, et al. Lab Invest. 2020 Oct;100(10):1330-1344. doi: 10.1038/s41374-020-0437-0. Epub 2020 May 13. Lab Invest. 2020. PMID: 32404931 Free article.
ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma.
De Bacco F, Orzan F, Erriquez J, Casanova E, Barault L, Albano R, D'Ambrosio A, Bigatto V, Reato G, Patanè M, Pollo B, Kuesters G, Dell'Aglio C, Casorzo L, Pellegatta S, Finocchiaro G, Comoglio PM, Boccaccio C. De Bacco F, et al. Among authors: orzan f. Cell Rep. 2021 Jul 27;36(4):109455. doi: 10.1016/j.celrep.2021.109455. Cell Rep. 2021. PMID: 34320350 Free article.
135 results