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Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice.
Seedorf K, Weber C, Vinson C, Berger S, Vuillard LM, Kiss A, Creusot S, Broux O, Geant A, Ilic C, Lemaitre K, Richard J, Hammoutene A, Mahieux J, Martiny V, Durand D, Melchiore F, Nyerges M, Paradis V, Provost N, Duvivier V, Delerive P. Seedorf K, et al. Among authors: broux o. JHEP Rep. 2022 Dec 16;5(4):100651. doi: 10.1016/j.jhepr.2022.100651. eCollection 2023 Apr. JHEP Rep. 2022. PMID: 36866391 Free PMC article.
Characterization and Pharmacological Validation of a Preclinical Model of NASH in Göttingen Minipigs.
Duvivier V, Creusot S, Broux O, Helbert A, Lesage L, Moreau K, Lesueur N, Gerard L, Lemaitre K, Provost N, Hubert EL, Baltauss T, Brzustowski A, De Preville N, Geronimi J, Adoux L, Letourneur F, Hammoutene A, Valla D, Paradis V, Delerive P. Duvivier V, et al. Among authors: broux o. J Clin Exp Hepatol. 2022 Mar-Apr;12(2):293-305. doi: 10.1016/j.jceh.2021.09.001. Epub 2021 Sep 8. J Clin Exp Hepatol. 2022. PMID: 35535064 Free PMC article.
Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans.
De Ceuninck F, Kargar C, Ilic C, Caliez A, Rolin JO, Umbdenstock T, Vinson C, Combettes M, de Fanti B, Harley E, Sadlo M, Lefèvre AL, Broux O, Wierzbicki M, Fourquez JM, Perron-Sierra F, Kotschy A, Ktorza A. De Ceuninck F, et al. Among authors: broux o. Br J Pharmacol. 2013 Jan;168(2):339-53. doi: 10.1111/j.1476-5381.2012.02184.x. Br J Pharmacol. 2013. PMID: 22925001 Free PMC article.
Lack of insulin resistance in the Lyon hypertensive rat.
Boulanger M, Duhault J, Broux O, Bataillard A, Sassard J. Boulanger M, et al. Among authors: broux o. Fundam Clin Pharmacol. 1997;11(6):546-9. doi: 10.1111/j.1472-8206.1997.tb00859.x. Fundam Clin Pharmacol. 1997. PMID: 9444522
Stimulatory Effect of Tofacitinib on Bone Marrow Adipocytes Differentiation.
Letarouilly JG, Paccou J, Badr S, Chauveau C, Broux O, Clabaut A. Letarouilly JG, et al. Among authors: broux o. Front Endocrinol (Lausanne). 2022 Jul 6;13:881699. doi: 10.3389/fendo.2022.881699. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35873000 Free PMC article.
49 results