Ruiz-Gómez G - Search Results

1

Dipeptide-Derived Alkynes as Potent and Selective Irreversible Inhibitors of Cysteine Cathepsins.

Behring L, Ruiz-Gómez G, Trapp C, Morales M, Wodtke R, Köckerling M, Kopka K, Pisabarro MT, Pietzsch J, Löser R. Behring L, et al. Among authors: ruiz gomez g. J Med Chem. 2023 Mar 23;66(6):3818-3851. doi: 10.1021/acs.jmedchem.2c01360. Epub 2023 Mar 3. J Med Chem. 2023. PMID: 36867428 Free PMC article.

2

Complement component C2, inhibiting a latent serine protease in the classical pathway of complement activation.

Halili MA, Ruiz-Gómez G, Le GT, Abbenante G, Fairlie DP. Halili MA, et al. Biochemistry. 2009 Sep 8;48(35):8466-72. doi: 10.1021/bi900679r. Biochemistry. 2009. PMID: 19642650

3

Helix-constrained nociceptin peptides are potent agonists and antagonists of ORL-1 and nociception.

Lohman RJ, Harrison RS, Ruiz-Gómez G, Hoang HN, Shepherd NE, Chow S, Hill TA, Madala PK, Fairlie DP. Lohman RJ, et al. Vitam Horm. 2015;97:1-55. doi: 10.1016/bs.vh.2014.10.001. Epub 2015 Jan 14. Vitam Horm. 2015. PMID: 25677767 Review.

4

Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1.

Rao T, Ruiz-Gómez G, Hill TA, Hoang HN, Fairlie DP, Mason JM. Rao T, et al. PLoS One. 2013;8(3):e59415. doi: 10.1371/journal.pone.0059415. Epub 2013 Mar 27. PLoS One. 2013. PMID: 23544065 Free PMC article.

5

Correction: Downsizing the BAD BH3 peptide to small constrained α-helices with improved ligand efficiency.

Shepherd NE, Harrison RS, Ruiz-Gomez G, Abbenante G, Mason JM, Fairlie DP. Shepherd NE, et al. Org Biomol Chem. 2016 Dec 28;14(48):11525. doi: 10.1039/c6ob90178f. Epub 2016 Nov 23. Org Biomol Chem. 2016. PMID: 27879976

6

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency.

Harrison RS, Shepherd NE, Hoang HN, Ruiz-Gómez G, Hill TA, Driver RW, Desai VS, Young PR, Abbenante G, Fairlie DP. Harrison RS, et al. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11686-91. doi: 10.1073/pnas.1002498107. Epub 2010 Jun 11. Proc Natl Acad Sci U S A. 2010. PMID: 20543141 Free PMC article.

7

Cyclopeptides containing the DEKS motif as conformationally restricted collagen telopeptide analogues: synthesis and conformational analysis.

Wodtke R, Ruiz-Gómez G, Kuchar M, Pisabarro MT, Novotná P, Urbanová M, Steinbach J, Pietzsch J, Löser R. Wodtke R, et al. Org Biomol Chem. 2015 Feb 14;13(6):1878-96. doi: 10.1039/c4ob02348j. Org Biomol Chem. 2015. PMID: 25503999

8

Rational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics.

Ruiz-Gómez G, Hawkins JC, Philipp J, Künze G, Wodtke R, Löser R, Fahmy K, Pisabarro MT. Ruiz-Gómez G, et al. PLoS One. 2016 Apr 28;11(4):e0154046. doi: 10.1371/journal.pone.0154046. eCollection 2016. PLoS One. 2016. PMID: 27123592 Free PMC article.

9

Sulfated hyaluronan improves bone regeneration of diabetic rats by binding sclerostin and enhancing osteoblast function.

Picke AK, Salbach-Hirsch J, Hintze V, Rother S, Rauner M, Kascholke C, Möller S, Bernhardt R, Rammelt S, Pisabarro MT, Ruiz-Gómez G, Schnabelrauch M, Schulz-Siegmund M, Hacker MC, Scharnweber D, Hofbauer C, Hofbauer LC. Picke AK, et al. Biomaterials. 2016 Jul;96:11-23. doi: 10.1016/j.biomaterials.2016.04.013. Epub 2016 Apr 21. Biomaterials. 2016. PMID: 27131598

10

Sulfated hyaluronan attenuates inflammatory signaling pathways in macrophages involving induction of antioxidants.

Jouy F, Lohmann N, Wandel E, Ruiz-Gómez G, Pisabarro MT, Beck-Sickinger AG, Schnabelrauch M, Möller S, Simon JC, Kalkhof S, von Bergen M, Franz S. Jouy F, et al. Proteomics. 2017 May;17(10):e1700082. doi: 10.1002/pmic.201700082. Proteomics. 2017. PMID: 28337837

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