Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients.
Wang TL, Diaz LA Jr, Romans K, Bardelli A, Saha S, Galizia G, Choti M, Donehower R, Parmigiani G, Shih IeM, Iacobuzio-Donahue C, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE.
Wang TL, et al.
Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3089-94. doi: 10.1073/pnas.0308716101. Epub 2004 Feb 17.
Proc Natl Acad Sci U S A. 2004.
PMID: 14970324
Free PMC article.