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Page 1
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
Coni S, Bordone R, Ivy DM, Yurtsever ZN, Di Magno L, D'Amico R, Cesaro B, Fatica A, Belardinilli F, Bufalieri F, Maroder M, De Smaele E, Di Marcotullio L, Giannini G, Agostinelli E, Canettieri G. Coni S, et al. Among authors: bordone r. Cancer Lett. 2023 Apr 10;559:216120. doi: 10.1016/j.canlet.2023.216120. Epub 2023 Mar 8. Cancer Lett. 2023. PMID: 36893894 Free article.
Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation.
Antonucci L, Di Magno L, D'Amico D, Manni S, Serrao SM, Di Pastena F, Bordone R, Yurtsever ZN, Caimano M, Petroni M, Giorgi A, Schininà ME, Yates Iii JR, Di Marcotullio L, De Smaele E, Checquolo S, Capalbo C, Agostinelli E, Maroder M, Coni S, Canettieri G. Antonucci L, et al. Among authors: bordone r. Int J Oncol. 2019 Feb;54(2):505-514. doi: 10.3892/ijo.2018.4638. Epub 2018 Nov 19. Int J Oncol. 2019. PMID: 30483764 Free PMC article.
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation.
Coni S, Serrao SM, Yurtsever ZN, Di Magno L, Bordone R, Bertani C, Licursi V, Ianniello Z, Infante P, Moretti M, Petroni M, Guerrieri F, Fatica A, Macone A, De Smaele E, Di Marcotullio L, Giannini G, Maroder M, Agostinelli E, Canettieri G. Coni S, et al. Among authors: bordone r. Cell Death Dis. 2020 Dec 10;11(12):1045. doi: 10.1038/s41419-020-03174-6. Cell Death Dis. 2020. PMID: 33303756 Free PMC article.
Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor.
Puxeddu M, Wu J, Bai R, D'Ambrosio M, Nalli M, Coluccia A, Manetto S, Ciogli A, Masci D, Urbani A, Fionda C, Coni S, Bordone R, Canettieri G, Bigogno C, Dondio G, Hamel E, Liu T, Silvestri R, La Regina G. Puxeddu M, et al. Among authors: bordone r. J Med Chem. 2022 Dec 8;65(23):15805-15818. doi: 10.1021/acs.jmedchem.2c01457. Epub 2022 Nov 17. J Med Chem. 2022. PMID: 36395526 Free PMC article.
4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells.
Masci D, Puxeddu M, Di Magno L, D'Ambrosio M, Parisi A, Nalli M, Bai R, Coluccia A, Sciò P, Orlando V, D'Angelo S, Biagioni S, Urbani A, Hamel E, Nocentini A, Filiberti S, Turati M, Ronca R, Kopecka J, Riganti C, Fionda C, Bordone R, Della Rocca G, Canettieri G, Supuran CT, Silvestri R, La Regina G. Masci D, et al. Among authors: bordone r. J Med Chem. 2023 Nov 9;66(21):14824-14842. doi: 10.1021/acs.jmedchem.3c01424. Epub 2023 Oct 30. J Med Chem. 2023. PMID: 37902628 Free PMC article.
MYC upstream region orchestrates resistance to PI3K inhibitors in cancer cells through FOXO3a-mediated autophagic adaptation.
Bordone R, Ivy DM, D'Amico R, Barba M, Gaggianesi M, Di Pastena F, Cesaro B, Bufalieri F, Balzerano A, De Smaele E, Giannini G, Di Marcotullio L, Fatica A, Stassi G, Di Magno L, Coni S, Canettieri G. Bordone R, et al. Oncogene. 2024 Nov;43(46):3349-3365. doi: 10.1038/s41388-024-03170-6. Epub 2024 Sep 22. Oncogene. 2024. PMID: 39306615
SMURF1 and SMURF2 directly target GLI1 for ubiquitination and proteasome-dependent degradation.
Bordin F, Terriaca G, Apostolico A, Di Fiore A, Mir FT, Bellardinelli S, Bufalieri F, Bordone R, Bellardinilli F, Giannini G, Canettieri G, Di Marcotullio L, Ferretti E, Moretti M, De Smaele E. Bordin F, et al. Among authors: bordone r. Cell Death Discov. 2024 Dec 18;10(1):498. doi: 10.1038/s41420-024-02260-4. Cell Death Discov. 2024. PMID: 39695131 Free PMC article.
29 results