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Page 1
Germline genetic variants are associated with development of insulin-dependent diabetes in cancer patients treated with immune checkpoint inhibitors.
Caulfield JI, Aizenbud L, Perdigoto AL, Meffre E, Jilaveanu L, Michalek DA, Rich SS, Aizenbud Y, Adeniran A, Herold KC, Austin MR, Kluger H. Caulfield JI, et al. Among authors: aizenbud l. J Immunother Cancer. 2023 Mar;11(3):e006570. doi: 10.1136/jitc-2022-006570. J Immunother Cancer. 2023. PMID: 36898736 Free PMC article.
IL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory.
Micevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn HN, Sefik E, Cheung JF, Hornick NI, Aizenbud L, Joshi NS, Kluger H, Iwasaki A, Bosenberg MW, Flavell RA. Micevic G, et al. Among authors: aizenbud l. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2304319120. doi: 10.1073/pnas.2304319120. Epub 2023 Jul 17. Proc Natl Acad Sci U S A. 2023. PMID: 37459511 Free PMC article.
ScRNA-seq defines dynamic T-cell subsets in longitudinal colon and peripheral blood samples in immune checkpoint inhibitor-induced colitis.
Mann JE, Lucca L, Austin MR, Merkin RD, Robert ME, Al Bawardy B, Raddassi K, Aizenbud L, Joshi NS, Hafler DA, Abraham C, Herold KC, Kluger HM. Mann JE, et al. Among authors: aizenbud l. J Immunother Cancer. 2023 Aug;11(8):e007358. doi: 10.1136/jitc-2023-007358. J Immunother Cancer. 2023. PMID: 37586769 Free PMC article.
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma.
Lu BY, Lucca LE, Lewis W, Wang J, Nogueira CV, Heer S, Rayon-Estrada V, Axisa PP, Reeves SM, Buitrago-Pocasangre NC, Pham GH, Kojima ML, Wei W, Aizenbud L, Bacchiocchi A, Zhang L, Walewski JJ, Chiang V, Olino K, Clune J, Halaban R, Kluger Y, Coyle AJ, Kisielow J, Obermair FJ, Kluger HM, Hafler DA. Lu BY, et al. Among authors: aizenbud l. Nat Immunol. 2025 Jan;26(1):82-91. doi: 10.1038/s41590-024-02023-4. Epub 2024 Nov 28. Nat Immunol. 2025. PMID: 39609626
Circulating Tumor Reactive KIR+CD8+ T cells Suppress Anti-Tumor Immunity in Patients with Melanoma.
Hafler D, Lu B, Lucca L, Lewis W, Wang J, Nogeuira C, Heer S, Axisa PP, Buitrago-Pocasangre N, Pham G, Kojima M, Wei W, Aizenbud L, Bacchiocchi A, Zhang L, Walewski J, Chiang V, Olino K, Clune J, Halaban R, Kluger Y, Coyle A, Kisielow J, Obermair FJ, Kluger H. Hafler D, et al. Among authors: aizenbud l. Res Sq [Preprint]. 2024 Feb 28:rs.3.rs-3956671. doi: 10.21203/rs.3.rs-3956671/v1. Res Sq. 2024. Update in: Nat Immunol. 2025 Jan;26(1):82-91. doi: 10.1038/s41590-024-02023-4 PMID: 38464315 Free PMC article. Updated. Preprint.