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Reference compounds for characterizing cellular injury in high-content cellular morphology assays.
Dahlin JL, Hua BK, Zucconi BE, Nelson SD Jr, Singh S, Carpenter AE, Shrimp JH, Lima-Fernandes E, Wawer MJ, Chung LPW, Agrawal A, O'Reilly M, Barsyte-Lovejoy D, Szewczyk M, Li F, Lak P, Cuellar M, Cole PA, Meier JL, Thomas T, Baell JB, Brown PJ, Walters MA, Clemons PA, Schreiber SL, Wagner BK. Dahlin JL, et al. Nat Commun. 2023 Mar 13;14(1):1364. doi: 10.1038/s41467-023-36829-x. Nat Commun. 2023. PMID: 36914634 Free PMC article.
How to Triage PAINS-Full Research.
Dahlin JL, Walters MA. Dahlin JL, et al. Assay Drug Dev Technol. 2016 Apr;14(3):168-74. doi: 10.1089/adt.2015.674. Epub 2015 Oct 23. Assay Drug Dev Technol. 2016. PMID: 26496388 Free PMC article.
ALARM NMR for HTS triage and chemical probe validation.
Dahlin JL, Cuellar M, Singh G, Nelson KM, Strasser J, Rappe T, Xia Y, Veglia G, Walters MA. Dahlin JL, et al. Curr Protoc Chem Biol. 2018 Mar;10(1):91-117. doi: 10.1002/cpch.35. Epub 2018 Apr 9. Curr Protoc Chem Biol. 2018. PMID: 30034947 Free PMC article.
Risk Management in Early Discovery Medicinal Chemistry.
Singh G, Dahlin JL, Walters MA. Singh G, et al. Among authors: dahlin jl. Methods Enzymol. 2018;610:1-25. doi: 10.1016/bs.mie.2018.09.012. Epub 2018 Oct 19. Methods Enzymol. 2018. PMID: 30390795
Nuisance compounds in cellular assays.
Dahlin JL, Auld DS, Rothenaigner I, Haney S, Sexton JZ, Nissink JWM, Walsh J, Lee JA, Strelow JM, Willard FS, Ferrins L, Baell JB, Walters MA, Hua BK, Hadian K, Wagner BK. Dahlin JL, et al. Cell Chem Biol. 2021 Mar 18;28(3):356-370. doi: 10.1016/j.chembiol.2021.01.021. Epub 2021 Feb 15. Cell Chem Biol. 2021. PMID: 33592188 Free PMC article. Review.
Mitigating risk in academic preclinical drug discovery.
Dahlin JL, Inglese J, Walters MA. Dahlin JL, et al. Nat Rev Drug Discov. 2015 Apr;14(4):279-94. doi: 10.1038/nrd4578. Nat Rev Drug Discov. 2015. PMID: 25829283 Free PMC article. Review.
98 results