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Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy.
Leow DM, Ng YK, Wang LC, Koh HW, Zhao T, Khong ZJ, Tabaglio T, Narayanan G, Giadone RM, Sobota RM, Ng SY, Teo AK, Parson SH, Rubin LL, Ong WY, Darras BT, Yeo CJ. Leow DM, et al. Among authors: giadone rm. J Clin Invest. 2024 May 9;134(12):e173702. doi: 10.1172/JCI173702. Online ahead of print. J Clin Invest. 2024. PMID: 38722695 Free PMC article.
A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring.
Dowrey TW, Cranston SF, Skvir N, Lok Y, Gould B, Petrowitz B, Villar D, Shan J, James M, Dodge M, Belkina AC, Giadone RM, Sebastiani P, Perls TT, Andersen SL, Murphy GJ. Dowrey TW, et al. Among authors: giadone rm. bioRxiv [Preprint]. 2024 Mar 14:2024.03.12.584663. doi: 10.1101/2024.03.12.584663. bioRxiv. 2024. Update in: Aging Cell. 2025 Jan;24(1):e14351. doi: 10.1111/acel.14351 PMID: 38559230 Free PMC article. Updated. Preprint.
Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition.
Edwards CV, Ferri GM, Villegas-Galaviz J, Ghosh S, Bawa PS, Wang F, Klimtchuk E, Ajayi TB, Morgan GJ, Prokaeva T, Staron A, Ruberg FL, Sanchorawala V, Giadone RM, Murphy GJ. Edwards CV, et al. Among authors: giadone rm. bioRxiv [Preprint]. 2024 Mar 16:2024.03.14.584987. doi: 10.1101/2024.03.14.584987. bioRxiv. 2024. PMID: 38558967 Free PMC article. Preprint.
Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types.
Ximerakis M, Holton KM, Giadone RM, Ozek C, Saxena M, Santiago S, Adiconis X, Dionne D, Nguyen L, Shah KM, Goldstein JM, Gasperini C, Gampierakis IA, Lipnick SL, Simmons SK, Buchanan SM, Wagers AJ, Regev A, Levin JZ, Rubin LL. Ximerakis M, et al. Among authors: giadone rm. Nat Aging. 2023 Mar;3(3):327-345. doi: 10.1038/s43587-023-00373-6. Epub 2023 Mar 9. Nat Aging. 2023. PMID: 37118429 Free PMC article.
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration.
Neel DV, Basu H, Gunner G, Bergstresser MD, Giadone RM, Chung H, Miao R, Chou V, Brody E, Jiang X, Lee E, Watts ME, Marques C, Held A, Wainger B, Lagier-Tourenne C, Zhang YJ, Petrucelli L, Young-Pearse TL, Chen-Plotkin AS, Rubin LL, Lieberman J, Chiu IM. Neel DV, et al. Among authors: giadone rm. Neuron. 2023 Apr 19;111(8):1222-1240.e9. doi: 10.1016/j.neuron.2023.02.019. Epub 2023 Mar 13. Neuron. 2023. PMID: 36917977 Free PMC article.
14 results