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Page 1
The BAF complex inhibitor pyrimethamine reverses HIV-1 latency in people with HIV-1 on antiretroviral therapy.
Prins HAB, Crespo R, Lungu C, Rao S, Li L, Overmars RJ, Papageorgiou G, Mueller YM, Stoszko M, Hossain T, Kan TW, Rijnders BJA, Bax HI, van Gorp ECM, Nouwen JL, de Vries-Sluijs TEMS, Schurink CAM, de Mendonça Melo M, van Nood E, Colbers A, Burger D, Palstra RJ, van Kampen JJA, van de Vijver DAMC, Mesplède T, Katsikis PD, Gruters RA, Koch BCP, Verbon A, Mahmoudi T, Rokx C. Prins HAB, et al. Among authors: kan tw. Sci Adv. 2023 Mar 17;9(11):eade6675. doi: 10.1126/sciadv.ade6675. Epub 2023 Mar 15. Sci Adv. 2023. PMID: 36921041 Free PMC article. Clinical Trial.
Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency.
Stoszko M, Al-Hatmi AMS, Skriba A, Roling M, Ne E, Crespo R, Mueller YM, Najafzadeh MJ, Kang J, Ptackova R, LeMasters E, Biswas P, Bertoldi A, Kan TW, de Crignis E, Sulc M, Lebbink JHG, Rokx C, Verbon A, van Ijcken W, Katsikis PD, Palstra RJ, Havlicek V, de Hoog S, Mahmoudi T. Stoszko M, et al. Among authors: kan tw. Sci Adv. 2020 Aug 12;6(33):eaba6617. doi: 10.1126/sciadv.aba6617. eCollection 2020 Aug. Sci Adv. 2020. PMID: 32851167 Free PMC article.
Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma.
De Crignis E, Hossain T, Romal S, Carofiglio F, Moulos P, Khalid MM, Rao S, Bazrafshan A, Verstegen MM, Pourfarzad F, Koutsothanassis C, Gehart H, Kan TW, Palstra RJ, Boucher C, IJzermans JN, Huch M, Boj SF, Vries R, Clevers H, van der Laan LJ, Hatzis P, Mahmoudi T. De Crignis E, et al. Among authors: kan tw. Elife. 2021 Jul 30;10:e60747. doi: 10.7554/eLife.60747. Elife. 2021. PMID: 34328417 Free PMC article.
PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency.
Crespo R, Ne E, Reinders J, Meier JIJ, Li C, Jansen S, Górska A, Koçer S, Kan TW, Doff W, Dekkers D, Demmers J, Palstra RJ, Rao S, Mahmoudi T. Crespo R, et al. Among authors: kan tw. iScience. 2024 Feb 6;27(3):109152. doi: 10.1016/j.isci.2024.109152. eCollection 2024 Mar 15. iScience. 2024. PMID: 38384833 Free PMC article.
Specific quantification of inducible HIV-1 reservoir by RT-LAMP.
Hossain T, Lungu C, de Schrijver S, Kuali M, Crespo R, Reddy N, Ngubane A, Kan TW, Reddy K, Rao S, Palstra RJ, Madlala P, Ndung'u T, Mahmoudi T. Hossain T, et al. Among authors: kan tw. Commun Med (Lond). 2024 Jun 25;4(1):123. doi: 10.1038/s43856-024-00553-4. Commun Med (Lond). 2024. PMID: 38918506 Free PMC article.
NPEPPS Is a Druggable Driver of Platinum Resistance.
Jones RT, Scholtes M, Goodspeed A, Akbarzadeh M, Mohapatra S, Feldman LE, Vekony H, Jean A, Tilton CB, Orman MV, Romal S, Deiter C, Kan TW, Xander N, Araki SP, Joshi M, Javaid M, Clambey ET, Layer R, Laajala TD, Parker SJ, Mahmoudi T, Zuiverloon TCM, Theodorescu D, Costello JC. Jones RT, et al. Among authors: kan tw. Cancer Res. 2024 May 15;84(10):1699-1718. doi: 10.1158/0008-5472.CAN-23-1976. Cancer Res. 2024. PMID: 38535994 Free PMC article.
18 results