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Discovery of N-substituted oseltamivir derivatives as novel neuraminidase inhibitors with improved drug resistance profiles and favorable drug-like properties.
Jia R, Zhang J, Shi F, Bonomini A, Lucca C, Bertagnin C, Zhang J, Liu C, Jia H, Jiang Y, Ma X, Loregian A, Huang B, Zhan P, Liu X. Jia R, et al. Among authors: huang b. Eur J Med Chem. 2023 Apr 5;252:115275. doi: 10.1016/j.ejmech.2023.115275. Epub 2023 Mar 13. Eur J Med Chem. 2023. PMID: 36931117
Elaborate Structural Modifications Yielding Novel Boron-Containing N-Substituted Oseltamivir Derivatives as Potent Neuraminidase Inhibitors with Significantly Improved Broad-Spectrum Antiresistance Profiles.
Zhang J, Jia R, Jia H, Li P, Jiang Y, Bonomini A, Bertagnin C, Xu Q, Tan Z, Ma X, Loregian A, Huang B, Liu X, Zhan P. Zhang J, et al. Among authors: huang b. J Med Chem. 2024 Dec 26;67(24):22191-22217. doi: 10.1021/acs.jmedchem.4c02222. Epub 2024 Dec 7. J Med Chem. 2024. PMID: 39644238
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