Grembecka J - Search Results

1

2-Aminobenzothiazoles in anticancer drug design and discovery.

Huang G, Cierpicki T, Grembecka J. Huang G, et al. Among authors: grembecka j. Bioorg Chem. 2023 Jun;135:106477. doi: 10.1016/j.bioorg.2023.106477. Epub 2023 Mar 20. Bioorg Chem. 2023. PMID: 36989736 Free PMC article. Review.

2

Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development.

Stack CM, Lowther J, Cunningham E, Donnelly S, Gardiner DL, Trenholme KR, Skinner-Adams TS, Teuscher F, Grembecka J, Mucha A, Kafarski P, Lua L, Bell A, Dalton JP. Stack CM, et al. Among authors: grembecka j. J Biol Chem. 2007 Jan 19;282(3):2069-80. doi: 10.1074/jbc.M609251200. Epub 2006 Nov 15. J Biol Chem. 2007. PMID: 17107951 Free article.

3

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.

McGowan S, Oellig CA, Birru WA, Caradoc-Davies TT, Stack CM, Lowther J, Skinner-Adams T, Mucha A, Kafarski P, Grembecka J, Trenholme KR, Buckle AM, Gardiner DL, Dalton JP, Whisstock JC. McGowan S, et al. Among authors: grembecka j. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2449-54. doi: 10.1073/pnas.0911813107. Epub 2010 Jan 21. Proc Natl Acad Sci U S A. 2010. PMID: 20133789 Free PMC article.

4

A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation.

Li Z, Lukasik SM, Liu Y, Grembecka J, Bielnicka I, Bushweller JH, Speck NA. Li Z, et al. Among authors: grembecka j. J Mol Biol. 2006 Dec 15;364(5):1073-83. doi: 10.1016/j.jmb.2006.10.002. Epub 2006 Oct 4. J Mol Biol. 2006. PMID: 17059830 Free PMC article.

5

Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials.

Skinner-Adams TS, Stack CM, Trenholme KR, Brown CL, Grembecka J, Lowther J, Mucha A, Drag M, Kafarski P, McGowan S, Whisstock JC, Gardiner DL, Dalton JP. Skinner-Adams TS, et al. Among authors: grembecka j. Trends Biochem Sci. 2010 Jan;35(1):53-61. doi: 10.1016/j.tibs.2009.08.004. Epub 2009 Sep 30. Trends Biochem Sci. 2010. PMID: 19796954 Review.

6

Leucine aminopeptidase as a target for inhibitor design.

Grembecka J, Kafarski P. Grembecka J, et al. Mini Rev Med Chem. 2001 Jul;1(2):133-44. doi: 10.2174/1389557013406990. Mini Rev Med Chem. 2001. PMID: 12369979 Review.

7

A phosphonamidate containing aromatic N-terminal amino group as inhibitor of leucine aminopeptidase-design, synthesis and stability.

Mucha A, Kunert A, Grembecka J, Pawełczak M, Kafarski P. Mucha A, et al. Among authors: grembecka j. Eur J Med Chem. 2006 Jun;41(6):768-72. doi: 10.1016/j.ejmech.2006.03.023. Epub 2006 May 11. Eur J Med Chem. 2006. PMID: 16690170

8

Exploring the Sn binding pockets in gingipains by newly developed inhibitors: structure-based design, chemistry, and activity.

Białas A, Grembecka J, Krowarsch D, Otlewski J, Potempa J, Mucha A. Białas A, et al. Among authors: grembecka j. J Med Chem. 2006 Mar 9;49(5):1744-53. doi: 10.1021/jm0600141. J Med Chem. 2006. PMID: 16509589

9

alpha-Aminoalkylphosphonates as a tool in experimental optimisation of P1 side chain shape of potential inhibitors in S1 pocket of leucine- and neutral aminopeptidases.

Drag M, Grembecka J, Pawełczak M, Kafarski P. Drag M, et al. Among authors: grembecka j. Eur J Med Chem. 2005 Aug;40(8):764-71. doi: 10.1016/j.ejmech.2005.02.011. Epub 2005 Apr 20. Eur J Med Chem. 2005. PMID: 16122579

10

Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta.

Gorczynski MJ, Grembecka J, Zhou Y, Kong Y, Roudaia L, Douvas MG, Newman M, Bielnicka I, Baber G, Corpora T, Shi J, Sridharan M, Lilien R, Donald BR, Speck NA, Brown ML, Bushweller JH. Gorczynski MJ, et al. Among authors: grembecka j. Chem Biol. 2007 Oct;14(10):1186-97. doi: 10.1016/j.chembiol.2007.09.006. Chem Biol. 2007. PMID: 17961830

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