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Page 1
Immune niches in brain metastases contain TCF1+ stem-like T cells, are associated with disease control and are modulated by preoperative SRS.
Jansen CS, Prabhu RS, Pagadala MS, Chappa P, Goyal S, Zhou C, Neill SG, Prokhnevska N, Cardenas M, Hoang KB, Zhong J, Torres M, Logan S, Olson JJ, Nduom EK, Del Balzo L, Patel K, Burri SH, Asher AL, Wilkinson S, Lake R, Higgins KA, Patel P, Dhere V, Sowalsky AG, Khan MK, Kissick H, Buchwald ZS. Jansen CS, et al. Among authors: chappa p. Res Sq [Preprint]. 2023 Mar 23:rs.3.rs-2722744. doi: 10.21203/rs.3.rs-2722744/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Oct 14;15(1):8854. doi: 10.1038/s41467-024-53034-6 PMID: 36993444 Free PMC article. Updated. Preprint.
Radiation and anti-PD-L1 synergize by stimulating a stem-like T cell population in the tumor-draining lymph node.
Shen Y, Connolly E, Aiello M, Zhou C, Chappa P, Song H, Tippitak P, Clark T, Cardenas M, Prokhnevska N, Mariniello A, Pagadala MS, Dhere VR, Rafiq S, Kesarwala AH, Orthwein A, Thomas SN, Khan MK, Brandon Dixon J, Lesinski GB, Lowe MC, Kissick H, Yu DS, Paulos CM, Schmitt NC, Buchwald ZS. Shen Y, et al. Among authors: chappa p. Res Sq [Preprint]. 2024 Mar 6:rs.3.rs-3921977. doi: 10.21203/rs.3.rs-3921977/v1. Res Sq. 2024. PMID: 38496632 Free PMC article. Preprint.
Pre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological correlates.
Jansen CS, Pagadala MS, Cardenas MA, Prabhu RS, Goyal S, Zhou C, Chappa P, Vo BT, Ye C, Hopkins B, Zhong J, Klie A, Daniels T, Admassu M, Green I, Pfister NT, Neill SG, Switchenko JM, Prokhnevska N, Hoang KB, Torres MA, Logan S, Olson JJ, Nduom EK, Del Balzo L, Patel K, Burri SH, Asher AL, Wilkinson S, Lake R, Kesarwala AH, Higgins KA, Patel P, Dhere V, Sowalsky AG, Carter H, Khan MK, Kissick H, Buchwald ZS. Jansen CS, et al. Among authors: chappa p. Nat Commun. 2024 Oct 14;15(1):8854. doi: 10.1038/s41467-024-53034-6. Nat Commun. 2024. PMID: 39402027 Free PMC article. Clinical Trial.
Interleukin-2-secreting T helper cells promote extra-follicular B cell maturation via intrinsic regulation of a B cell mTOR-AKT-Blimp-1 axis.
Faliti CE, Mesina M, Choi J, Bélanger S, Marshall MA, Tipton CM, Hicks S, Chappa P, Cardenas MA, Abdel-Hakeem M, Thinnes TC, Cottrell C, Scharer CD, Schief WR, Nemazee D, Woodruff MC, Lindner JM, Sanz I, Crotty S. Faliti CE, et al. Among authors: chappa p. Immunity. 2024 Dec 10;57(12):2772-2789.e8. doi: 10.1016/j.immuni.2024.11.006. Epub 2024 Nov 28. Immunity. 2024. PMID: 39612915
Lectins identify glycan biomarkers on glioblastoma-derived cancer stem cells.
Tucker-Burden C, Chappa P, Krishnamoorthy M, Gerwe BA, Scharer CD, Heimburg-Molinaro J, Harris W, Usta SN, Eilertson CD, Hadjipanayis CG, Stice SL, Brat DJ, Nash RJ. Tucker-Burden C, et al. Among authors: chappa p. Stem Cells Dev. 2012 Sep 1;21(13):2374-86. doi: 10.1089/scd.2011.0369. Epub 2012 Apr 27. Stem Cells Dev. 2012. PMID: 22435486 Free PMC article.
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