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Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1.
Abini-Agbomson S, Gretarsson K, Shih RM, Hsieh L, Lou T, De Ioannes P, Vasilyev N, Lee R, Wang M, Simon M, Armache JP, Nudler E, Narlikar G, Liu S, Lu C, Armache KJ. Abini-Agbomson S, et al. Among authors: lu c. bioRxiv [Preprint]. 2023 Mar 19:2023.03.17.533220. doi: 10.1101/2023.03.17.533220. bioRxiv. 2023. Update in: Mol Cell. 2023 Aug 17;83(16):2872-2883.e7. doi: 10.1016/j.molcel.2023.07.020 PMID: 36993485 Free PMC article. Updated. Preprint.
Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1.
Thomas JF, Valencia-Sánchez MI, Tamburri S, Gloor SL, Rustichelli S, Godínez-López V, De Ioannes P, Lee R, Abini-Agbomson S, Gretarsson K, Burg JM, Hickman AR, Sun L, Gopinath S, Taylor H, Meiners MJ, Cheek MA, Rice W, Nudler E, Lu C, Keogh MC, Pasini D, Armache KJ. Thomas JF, et al. Among authors: lu c. bioRxiv [Preprint]. 2023 Feb 23:2023.02.23.529554. doi: 10.1101/2023.02.23.529554. bioRxiv. 2023. Update in: Sci Adv. 2023 Aug 9;9(32):eadg9832. doi: 10.1126/sciadv.adg9832 PMID: 36865140 Free PMC article. Updated. Preprint.
H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs.
Krug B, Hu B, Chen H, Ptack A, Chen X, Gretarsson KH, Deshmukh S, Kabir N, Andrade AF, Jabbour E, Harutyunyan AS, Lee JJY, Hulswit M, Faury D, Russo C, Xu X, Johnston MJ, Baguette A, Dahl NA, Weil AG, Ellezam B, Dali R, Blanchette M, Wilson K, Garcia BA, Soni RK, Gallo M, Taylor MD, Kleinman CL, Majewski J, Jabado N, Lu C. Krug B, et al. Among authors: lu c. bioRxiv [Preprint]. 2023 Nov 28:2023.11.28.567931. doi: 10.1101/2023.11.28.567931. bioRxiv. 2023. PMID: 38116029 Free PMC article. Preprint.
Systematic perturbations of SETD2, NSD1, NSD2, NSD3 and ASH1L reveals their distinct contributions to H3K36 methylation.
Shipman GA, Padilla R, Horth C, Hu B, Bareke E, Vitorino FN, Gongora JM, Garcia BA, Lu C, Majewski J. Shipman GA, et al. Among authors: lu c. bioRxiv [Preprint]. 2023 Oct 18:2023.09.27.559313. doi: 10.1101/2023.09.27.559313. bioRxiv. 2023. Update in: Genome Biol. 2024 Oct 10;25(1):263. doi: 10.1186/s13059-024-03415-3 PMID: 37905045 Free PMC article. Updated. Preprint.
Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors.
Karagiannis D, Wu W, Li A, Hayashi M, Chen X, Yip M, Mangipudy V, Xu X, Sánchez-Rivera FJ, Soto-Feliciano YM, Ye J, Papagiannakopoulos T, Lu C. Karagiannis D, et al. Among authors: lu c. bioRxiv [Preprint]. 2023 Apr 28:2023.04.24.538118. doi: 10.1101/2023.04.24.538118. bioRxiv. 2023. Update in: Cell Rep. 2024 Jan 23;43(1):113629. doi: 10.1016/j.celrep.2023.113629 PMID: 37162970 Free PMC article. Updated. Preprint.
NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancer.
Li JJ, Vasciaveo A, Karagiannis D, Sun Z, Chen X, Socciarelli F, Frankenstein Z, Zou M, Pannellini T, Chen Y, Gardner K, Robinson BD, de Bono J, Abate-Shen C, Rubin MA, Loda M, Sawyers CL, Califano A, Lu C, Shen MM. Li JJ, et al. Among authors: lu c. bioRxiv [Preprint]. 2023 Jul 19:2023.07.18.549585. doi: 10.1101/2023.07.18.549585. bioRxiv. 2023. PMID: 37502956 Free PMC article. Preprint.
Combined Mek inhibition and Pparg activation Eradicates Muscle Invasive Bladder cancer in a Mouse Model of BBN-induced Carcinogenesis.
Tate T, Plumber SA, Al-Ahmadie H, Chen X, Choi W, Lu C, Viny A, Batourina E, Gartensson K, Alija B, Molotkov A, Wiessner G, McKiernan J, McConkey D, Dinney C, Czerniak B, Mendelsohn CL. Tate T, et al. Among authors: lu c. bioRxiv [Preprint]. 2023 Aug 21:2023.08.19.553961. doi: 10.1101/2023.08.19.553961. bioRxiv. 2023. PMID: 37662238 Free PMC article. Preprint.
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