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Subclass-switched anti-spike IgG3 oligoclonal cocktails strongly enhance Fc-mediated opsonization.
Izadi A, Hailu A, Godzwon M, Wrighton S, Olofsson B, Schmidt T, Söderlund-Strand A, Elder E, Appelberg S, Valsjö M, Larsson O, Wendel-Hansen V, Ohlin M, Bahnan W, Nordenfelt P. Izadi A, et al. Among authors: schmidt t. Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2217590120. doi: 10.1073/pnas.2217590120. Epub 2023 Apr 3. Proc Natl Acad Sci U S A. 2023. PMID: 37011197 Free PMC article.
The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies.
Izadi A, Karami Y, Bratanis E, Wrighton S, Khakzad H, Nyblom M, Olofsson B, Happonen L, Tang D, Sundwall M, Godzwon M, Chao Y, Toledo AG, Schmidt T, Ohlin M, Nilges M, Malmström J, Bahnan W, Shannon O, Malmström L, Nordenfelt P. Izadi A, et al. Among authors: schmidt t. Nat Commun. 2024 Apr 27;15(1):3600. doi: 10.1038/s41467-024-47928-8. Nat Commun. 2024. PMID: 38678029 Free PMC article.
Protective Non-neutralizing anti-N-terminal Domain mAb Maintains Fc-mediated Function against SARS-COV-2 Variants up to BA.2.86-JN.1 with Superfluous In Vivo Protection against JN.1 Due to Attenuated Virulence.
Izadi A, Godzwon M, Söderlund Strand A, Schmidt T, Kumlien Georén S, Drosten C, Ohlin M, Nordenfelt P. Izadi A, et al. Among authors: schmidt t. J Immunol. 2024 Sep 1;213(5):678-689. doi: 10.4049/jimmunol.2300675. J Immunol. 2024. PMID: 39018495 Free PMC article.
Children with oligoarticular juvenile idiopathic arthritis have skewed synovial monocyte polarization pattern with functional impairment-a distinct inflammatory pattern for oligoarticular juvenile arthritis.
Schmidt T, Berthold E, Arve-Butler S, Gullstrand B, Mossberg A, Kahn F, Bengtsson AA, Månsson B, Kahn R. Schmidt T, et al. Arthritis Res Ther. 2020 Aug 12;22(1):186. doi: 10.1186/s13075-020-02279-9. Arthritis Res Ther. 2020. PMID: 32787920 Free PMC article.
3,883 results