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Page 1
A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer.
Mayoh C, Gifford AJ, Terry R, Lau LMS, Wong M, Rao P, Shai-Hee T, Saletta F, Khuong-Quang DA, Qin V, Mateos MK, Meyran D, Miller KE, Yuksel A, Mould EVA, Bowen-James R, Govender D, Senapati A, Zhukova N, Omer N, Dholaria H, Alvaro F, Tapp H, Diamond Y, Pozza LD, Moore AS, Nicholls W, Gottardo NG, McCowage G, Hansford JR, Khaw SL, Wood PJ, Catchpoole D, Cottrell CE, Mardis ER, Marshall GM, Tyrrell V, Haber M, Ziegler DS, Vittorio O, Trapani JA, Cowley MJ, Neeson PJ, Ekert PG. Mayoh C, et al. Among authors: trapani ja. Genome Med. 2023 Apr 3;15(1):20. doi: 10.1186/s13073-023-01170-x. Genome Med. 2023. PMID: 37013636 Free PMC article.
Low-dose carboplatin modifies the tumor microenvironment to augment CAR T cell efficacy in human prostate cancer models.
Porter LH, Zhu JJ, Lister NL, Harrison SG, Keerthikumar S, Goode DL, Urban RQ, Byrne DJ, Azad A, Vela I, Hofman MS, Neeson PJ, Darcy PK, Trapani JA, Taylor RA, Risbridger GP. Porter LH, et al. Among authors: trapani ja. Nat Commun. 2023 Sep 2;14(1):5346. doi: 10.1038/s41467-023-40852-3. Nat Commun. 2023. PMID: 37660083 Free PMC article.
Effects of a Small-Molecule Perforin Inhibitor in a Mouse Model of CD8 T Cell-Mediated Neuroinflammation.
Gonzalez-Fierro C, Fonte C, Dufourd E, Cazaentre V, Aydin S, Engelhardt B, Caspi RR, Xu B, Martin-Blondel G, Spicer JA, Trapani JA, Bauer J, Liblau RS, Bost C. Gonzalez-Fierro C, et al. Among authors: trapani ja. Neurol Neuroimmunol Neuroinflamm. 2023 Apr 20;10(4):e200117. doi: 10.1212/NXI.0000000000200117. Print 2023 Jul. Neurol Neuroimmunol Neuroinflamm. 2023. PMID: 37080596 Free PMC article.
The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects.
Van Der Byl W, Nüssing S, Peters TJ, Ahn A, Li H, Ledergor G, David E, Koh AS, Wagle MV, Deguit CDT, de Menezes MN, Travers A, Sampurno S, Ramsbottom KM, Li R, Kallies A, Beavis PA, Jungmann R, Bastings MMC, Belz GT, Goel S, Trapani JA, Crabtree GR, Chang HY, Amit I, Goodnow CC, Luciani F, Parish IA. Van Der Byl W, et al. Among authors: trapani ja. Immunity. 2024 Jun 11;57(6):1324-1344.e8. doi: 10.1016/j.immuni.2024.04.026. Epub 2024 May 21. Immunity. 2024. PMID: 38776918
Fragment-based and structure-guided discovery of perforin inhibitors.
Jose J, Law RHP, Leung EWW, Wai DCC, Akhlaghi H, Chandrashekaran IR, Caradoc-Davies TT, Voskoboinik I, Feutrill J, Middlemiss D, Jeevarajah D, Bashtannyk-Puhalovich T, Giddens AC, Lee TW, Jamieson SMF, Trapani JA, Whisstock JC, Spicer JA, Norton RS. Jose J, et al. Among authors: trapani ja. Eur J Med Chem. 2023 Dec 5;261:115786. doi: 10.1016/j.ejmech.2023.115786. Epub 2023 Sep 1. Eur J Med Chem. 2023. PMID: 37716187 Free article.
CRISPR-Cas13b-mediated suppression of HBV replication and protein expression.
McCoullough LC, Fareh M, Hu W, Sozzi V, Makhlouf C, Droungas Y, Lee CL, Takawy M, Fabb SA, Payne TJ, Pouton CW, Netter HJ, Lewin SR, Purcell DF, Holmes JA, Trapani JA, Littlejohn M, Revill PA. McCoullough LC, et al. Among authors: trapani ja. J Hepatol. 2024 Nov;81(5):794-805. doi: 10.1016/j.jhep.2024.05.025. Epub 2024 May 28. J Hepatol. 2024. PMID: 38815932 Free article.
Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity.
Pedde AM, Kim H, Donakonda S, Baumann T, Bayerl F, Meiser P, Hirschberger A, Klement C, Grassmann S, Öllinger R, Hüser N, Hartmann D, Laschinger M, Trapani JA, Zippelius A, Bald T, Wiedemann GM, Rad R, Sun JC, Höchst B, Böttcher JP. Pedde AM, et al. Among authors: trapani ja. Cell Rep. 2024 Nov 26;43(11):114855. doi: 10.1016/j.celrep.2024.114855. Epub 2024 Nov 13. Cell Rep. 2024. PMID: 39541209 Free article.
Acidic pH can attenuate immune killing through inactivation of perforin.
Hodel AW, Rudd-Schmidt JA, Noori T, Lupton CJ, Cheuk VCT, Trapani JA, Hoogenboom BW, Voskoboinik I. Hodel AW, et al. Among authors: trapani ja. EMBO Rep. 2025 Jan 9. doi: 10.1038/s44319-024-00365-6. Online ahead of print. EMBO Rep. 2025. PMID: 39789387 Free article.
339 results