Christianson DW - Search Results

1

Macrocyclic Octapeptide Binding and Inferences on Protein Substrate Binding to Histone Deacetylase 6.

Watson PR, Gupta S, Hosseinzadeh P, Brown BP, Baker D, Christianson DW. Watson PR, et al. Among authors: christianson dw. ACS Chem Biol. 2023 Apr 21;18(4):959-968. doi: 10.1021/acschembio.3c00113. Epub 2023 Apr 7. ACS Chem Biol. 2023. PMID: 37027789 Free PMC article.

2

Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases.

Cole KE, Dowling DP, Boone MA, Phillips AJ, Christianson DW. Cole KE, et al. Among authors: christianson dw. J Am Chem Soc. 2011 Aug 17;133(32):12474-7. doi: 10.1021/ja205972n. Epub 2011 Jul 26. J Am Chem Soc. 2011. PMID: 21790156 Free PMC article.

3

Compromised structure and function of HDAC8 mutants identified in Cornelia de Lange Syndrome spectrum disorders.

Decroos C, Bowman CM, Moser JA, Christianson KE, Deardorff MA, Christianson DW. Decroos C, et al. Among authors: christianson dw, christianson ke. ACS Chem Biol. 2014 Sep 19;9(9):2157-64. doi: 10.1021/cb5003762. Epub 2014 Jul 30. ACS Chem Biol. 2014. PMID: 25075551 Free PMC article.

4

Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase.

Chen M, Chou WK, Toyomasu T, Cane DE, Christianson DW. Chen M, et al. Among authors: christianson dw. ACS Chem Biol. 2016 Apr 15;11(4):889-99. doi: 10.1021/acschembio.5b00960. Epub 2016 Jan 6. ACS Chem Biol. 2016. PMID: 26734760 Free PMC article.

5

Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.

Hai Y, Christianson DW. Hai Y, et al. Among authors: christianson dw. Nat Chem Biol. 2016 Sep;12(9):741-7. doi: 10.1038/nchembio.2134. Epub 2016 Jul 25. Nat Chem Biol. 2016. PMID: 27454933 Free PMC article.

6

Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8.

Porter NJ, Christianson DW. Porter NJ, et al. Among authors: christianson dw. ACS Chem Biol. 2017 Sep 15;12(9):2281-2286. doi: 10.1021/acschembio.7b00330. Epub 2017 Aug 30. ACS Chem Biol. 2017. PMID: 28846375 Free PMC article.

7

Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6.

Porter NJ, Wagner FF, Christianson DW. Porter NJ, et al. Among authors: christianson dw. Biochemistry. 2018 Jul 3;57(26):3916-3924. doi: 10.1021/acs.biochem.8b00367. Epub 2018 May 18. Biochemistry. 2018. PMID: 29775292 Free PMC article.

8

Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor.

Porter NJ, Shen S, Barinka C, Kozikowski AP, Christianson DW. Porter NJ, et al. Among authors: christianson dw. ACS Med Chem Lett. 2018 Nov 21;9(12):1301-1305. doi: 10.1021/acsmedchemlett.8b00487. eCollection 2018 Dec 13. ACS Med Chem Lett. 2018. PMID: 30613344 Free PMC article.

9

Structure of Sesquisabinene Synthase 1, a Terpenoid Cyclase That Generates a Strained [3.1.0] Bridged-Bicyclic Product.

Blank PN, Shinsky SA, Christianson DW. Blank PN, et al. Among authors: christianson dw. ACS Chem Biol. 2019 May 17;14(5):1011-1019. doi: 10.1021/acschembio.9b00218. Epub 2019 Apr 17. ACS Chem Biol. 2019. PMID: 30977996 Free PMC article.

10

Structural determinants of affinity and selectivity in the binding of inhibitors to histone deacetylase 6.

Osko JD, Christianson DW. Osko JD, et al. Among authors: christianson dw. Bioorg Med Chem Lett. 2020 Apr 15;30(8):127023. doi: 10.1016/j.bmcl.2020.127023. Epub 2020 Feb 11. Bioorg Med Chem Lett. 2020. PMID: 32067866 Free PMC article. Review.

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