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CD8+ T cells promote HIV latency by remodeling CD4+ T cell metabolism to enhance their survival, quiescence, and stemness.
Mutascio S, Mota T, Franchitti L, Sharma AA, Willemse A, Bergstresser SN, Wang H, Statzu M, Tharp GK, Weiler J, Sékaly RP, Bosinger SE, Paiardini M, Silvestri G, Jones RB, Kulpa DA. Mutascio S, et al. Among authors: sharma aa. Immunity. 2023 May 9;56(5):1132-1147.e6. doi: 10.1016/j.immuni.2023.03.010. Epub 2023 Apr 7. Immunity. 2023. PMID: 37030290 Free PMC article.
Neutralization activity in chronic HIV infection is characterized by a distinct programming of follicular helper CD4 T cells.
Moysi E, Sharma AA, O'Dell S, Georgakis S, Del Rio Estrada PM, Torres-Ruiz F, Navarro MG, Villalobos YAL, Rios SA, Reyes-Teran G, Beddall MH, Ko SH, Belinky F, Orfanakis M, de Leval L, Enriquez AB, Buckner CM, Moir S, Doria-Rose N, Boritz E, Mascola JR, Sekaly RP, Koup RA, Petrovas C. Moysi E, et al. Among authors: sharma aa. bioRxiv [Preprint]. 2024 Aug 3:2024.07.31.605954. doi: 10.1101/2024.07.31.605954. bioRxiv. 2024. PMID: 39131331 Free PMC article. Preprint.
Passive Transfer of Vaccine-Elicited Antibodies Protects against SIV in Rhesus Macaques.
Alter G, Yu WH, Chandrashekar A, Borducchi EN, Ghneim K, Sharma A, Nedellec R, McKenney KR, Linde C, Broge T, Suscovich TJ, Linnekin T, Abbink P, Mercado NB, Nkolola JP, McMahan K, Bondzie EA, Hamza V, Peter L, Kordana N, Mahrokhian S, Seaman MS, Li W, Lewis MG, Lauffenburger DA, Hangartner L, Sekaly RP, Barouch DH. Alter G, et al. Cell. 2020 Oct 1;183(1):185-196.e14. doi: 10.1016/j.cell.2020.08.033. Cell. 2020. PMID: 33007262 Free PMC article.
Anisocytosis is Associated With Short-Term Mortality in COVID-19 and May Reflect Proinflammatory Signature in Uninfected Ambulatory Adults.
Hornick A, Tashtish N, Osnard M, Shah B, Bradigan A, Albar Z, Tomalka J, Dalton J, Sharma A, Sekaly RP, Hejal R, Simon DI, Zidar DA, Al-Kindi SG; Inaction Study Group.. Hornick A, et al. Pathog Immun. 2020 Oct 2;5(1):312-326. doi: 10.20411/pai.v5i1.391. eCollection 2020. Pathog Immun. 2020. PMID: 33089037 Free PMC article.
The transcription factor CREB1 is a mechanistic driver of immunogenicity and reduced HIV-1 acquisition following ALVAC vaccination.
Tomalka JA, Pelletier AN, Fourati S, Latif MB, Sharma A, Furr K, Carlson K, Lifton M, Gonzalez A, Wilkinson P, Franchini G, Parks R, Letvin N, Yates N, Seaton K, Tomaras G, Tartaglia J, Robb ML, Michael NL, Koup R, Haynes B, Santra S, Sekaly RP. Tomalka JA, et al. Nat Immunol. 2021 Oct;22(10):1294-1305. doi: 10.1038/s41590-021-01026-9. Epub 2021 Sep 23. Nat Immunol. 2021. PMID: 34556879 Free PMC article.
Combined cerebrospinal fluid metabolomic and cytokine profiling in tuberculosis meningitis reveals robust and prolonged changes in immunometabolic networks.
Tomalka J, Sharma A, Smith AGC, Avaliani T, Gujabidze M, Bakuradze T, Sabanadze S, Jones DP, Avaliani Z, Kipiani M, Kempker RR, Collins JM. Tomalka J, et al. Tuberculosis (Edinb). 2024 Jan;144:102462. doi: 10.1016/j.tube.2023.102462. Epub 2023 Dec 2. Tuberculosis (Edinb). 2024. PMID: 38070353 Free PMC article.
79 results