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Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct.
Gehrlein A, Udayar V, Anastasi N, Morella ML, Ruf I, Brugger D, von der Mark S, Thoma R, Rufer A, Heer D, Pfahler N, Jochner A, Niewoehner J, Wolf L, Fueth M, Ebeling M, Villaseñor R, Zhu Y, Deen MC, Shan X, Ehsaei Z, Taylor V, Sidransky E, Vocadlo DJ, Freskgård PO, Jagasia R. Gehrlein A, et al. Among authors: niewoehner j. Nat Commun. 2023 Apr 12;14(1):2057. doi: 10.1038/s41467-023-37632-4. Nat Commun. 2023. PMID: 37045813 Free PMC article.
Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport.
Ruderisch N, Schlatter D, Kuglstatter A, Guba W, Huber S, Cusulin C, Benz J, Rufer AC, Hoernschemeyer J, Schweitzer C, Bülau T, Gärtner A, Hoffmann E, Niewoehner J, Patsch C, Baumann K, Loetscher H, Kitas E, Freskgård PO. Ruderisch N, et al. Among authors: niewoehner j. EBioMedicine. 2017 Oct;24:76-92. doi: 10.1016/j.ebiom.2017.09.004. Epub 2017 Sep 7. EBioMedicine. 2017. PMID: 28923680 Free PMC article.
First Infusion Reactions are Mediated by FcγRIIIb and Neutrophils.
Weber F, Breustedt D, Schlicht S, Meyer CA, Niewoehner J, Ebeling M, Freskgard PO, Bruenker P, Singer T, Reth M, Iglesias A. Weber F, et al. Among authors: niewoehner j. Pharm Res. 2018 Jun 27;35(9):169. doi: 10.1007/s11095-018-2448-8. Pharm Res. 2018. PMID: 29951887 Free PMC article.
Brain Shuttle Neprilysin reduces central Amyloid-β levels.
Campos CR, Kemble AM, Niewoehner J, Freskgård PO, Urich E. Campos CR, et al. Among authors: niewoehner j. PLoS One. 2020 Mar 10;15(3):e0229850. doi: 10.1371/journal.pone.0229850. eCollection 2020. PLoS One. 2020. PMID: 32155191 Free PMC article.
Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans.
Grimm HP, Schumacher V, Schäfer M, Imhof-Jung S, Freskgård PO, Brady K, Hofmann C, Rüger P, Schlothauer T, Göpfert U, Hartl M, Rottach S, Zwick A, Seger S, Neff R, Niewoehner J, Janssen N. Grimm HP, et al. Among authors: niewoehner j. MAbs. 2023 Jan-Dec;15(1):2261509. doi: 10.1080/19420862.2023.2261509. Epub 2023 Oct 12. MAbs. 2023. PMID: 37823690 Free PMC article.
37 results