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Page 1
A novel thiol-saccharide mucolytic for the treatment of muco-obstructive lung diseases.
Addante A, Raymond W, Gitlin I, Charbit A, Orain X, Scheffler AW, Kuppe A, Duerr J, Daniltchenko M, Drescher M, Graeber SY, Healy AM, Oscarson S, Fahy JV, Mall MA. Addante A, et al. Among authors: charbit a. Eur Respir J. 2023 May 25;61(5):2202022. doi: 10.1183/13993003.02022-2022. Print 2023 May. Eur Respir J. 2023. PMID: 37080569 Free PMC article.
Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma.
Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV. Lachowicz-Scroggins ME, et al. Among authors: charbit ar. Am J Respir Crit Care Med. 2019 May 1;199(9):1076-1085. doi: 10.1164/rccm.201810-1869OC. Am J Respir Crit Care Med. 2019. PMID: 30888839 Free PMC article.
Thiol drugs decrease SARS-CoV-2 lung injury in vivo and disrupt SARS-CoV-2 spike complex binding to ACE2 in vitro.
Khanna K, Raymond W, Jin J, Charbit AR, Gitlin I, Tang M, Werts AD, Barrett EG, Cox JM, Birch SM, Martinelli R, Sperber HS, Franz S, Pillai S, Healy AM, Duff T, Oscarson S, Hoffmann M, Pöhlmann S, Simmons G, Fahy JV. Khanna K, et al. bioRxiv [Preprint]. 2021 Nov 11:2020.12.08.415505. doi: 10.1101/2020.12.08.415505. bioRxiv. 2021. PMID: 33330868 Free PMC article. Preprint.
Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19.
Khanna K, Raymond WW, Jin J, Charbit AR, Gitlin I, Tang M, Werts AD, Barrett EG, Cox JM, Birch SM, Martinelli R, Sperber HS, Franz S, Duff T, Hoffmann M, Healy AM, Oscarson S, Pöhlmann S, Pillai SK, Simmons G, Fahy JV. Khanna K, et al. Among authors: charbit ar. Am J Physiol Lung Cell Mol Physiol. 2022 Sep 1;323(3):L372-L389. doi: 10.1152/ajplung.00136.2022. Epub 2022 Jun 28. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35762590 Free PMC article.
A novel DNase assay reveals low DNase activity in severe asthma.
Charbit AR, Liegeois MA, Raymond WW, Comhair SAA, Johansson MW, Hastie AT, Bleecker ER, Fajt M, Castro M, Sumino K, Erzurum SC, Israel E, Jarjour NN, Mauger DT, Moore WC, Wenzel SE, Woodruff PG, Levy BD, Tang MC, Fahy JV. Charbit AR, et al. Am J Physiol Lung Cell Mol Physiol. 2024 Jun 1;326(6):L796-L804. doi: 10.1152/ajplung.00081.2024. Epub 2024 Apr 23. Am J Physiol Lung Cell Mol Physiol. 2024. PMID: 38651338
Utility of eosinophil peroxidase as a biomarker of eosinophilic inflammation in asthma.
Tang M, Charbit AR, Johansson MW, Jarjour NN, Denlinger LC, Raymond WW, Peters MC, Dunican EM, Castro M, Sumino K, Erzurum SC, Comhair SA, Moore WC, Levy BD, Israel E, Phipatanakul W, Phillips BR, Mauger DT, Bleecker ER, Wenzel SE, Fajt ML, Woodruff PG, Hastie AT, Fahy JV; National Heart Lung and Blood Institute Severe Asthma Research Program. Tang M, et al. Among authors: charbit ar. J Allergy Clin Immunol. 2024 Sep;154(3):580-591.e6. doi: 10.1016/j.jaci.2024.03.023. Epub 2024 Apr 23. J Allergy Clin Immunol. 2024. PMID: 38663815 Free article.
Peroxidase-mediated mucin cross-linking drives pathologic mucus gel formation in IL-13-stimulated airway epithelial cells.
Liegeois MA, Braunreuther M, Charbit AR, Raymond WW, Tang M, Woodruff PG, Christenson SA, Castro M, Erzurum SC, Israel E, Jarjour NN, Levy BD, Moore WC, Wenzel SE, Fuller GG, Fahy JV. Liegeois MA, et al. Among authors: charbit ar. JCI Insight. 2024 Jun 18;9(15):e181024. doi: 10.1172/jci.insight.181024. JCI Insight. 2024. PMID: 38889046 Free PMC article.
Quantitative CT Characteristics of Cluster Phenotypes in the Severe Asthma Research Program Cohorts.
Trivedi AP, Hall C, Goss CW, Lew D, Krings JG, McGregor MC, Samant M, Sieren JP, Li H, Schechtman KB, Schirm J, McEleney S, Peterson S, Moore WC, Bleecker ER, Meyers DA, Israel E, Washko GR, Levy BD, Leader JK, Wenzel SE, Fahy JV, Schiebler ML, Fain SB, Jarjour NN, Mauger DT, Reinhardt JM, Newell JD Jr, Hoffman EA, Castro M, Sheshadri A; NHLBI Severe Asthma Research Program (SARP). Trivedi AP, et al. Radiology. 2022 Aug;304(2):450-459. doi: 10.1148/radiol.210363. Epub 2022 Apr 26. Radiology. 2022. PMID: 35471111 Free PMC article.
178 results