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A novel thiol-saccharide mucolytic for the treatment of muco-obstructive lung diseases.
Addante A, Raymond W, Gitlin I, Charbit A, Orain X, Scheffler AW, Kuppe A, Duerr J, Daniltchenko M, Drescher M, Graeber SY, Healy AM, Oscarson S, Fahy JV, Mall MA. Addante A, et al. Among authors: healy am. Eur Respir J. 2023 May 25;61(5):2202022. doi: 10.1183/13993003.02022-2022. Print 2023 May. Eur Respir J. 2023. PMID: 37080569 Free PMC article.
Thiol drugs decrease SARS-CoV-2 lung injury in vivo and disrupt SARS-CoV-2 spike complex binding to ACE2 in vitro.
Khanna K, Raymond W, Jin J, Charbit AR, Gitlin I, Tang M, Werts AD, Barrett EG, Cox JM, Birch SM, Martinelli R, Sperber HS, Franz S, Pillai S, Healy AM, Duff T, Oscarson S, Hoffmann M, Pöhlmann S, Simmons G, Fahy JV. Khanna K, et al. Among authors: healy am. bioRxiv [Preprint]. 2021 Nov 11:2020.12.08.415505. doi: 10.1101/2020.12.08.415505. bioRxiv. 2021. PMID: 33330868 Free PMC article. Preprint.
Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19.
Khanna K, Raymond WW, Jin J, Charbit AR, Gitlin I, Tang M, Werts AD, Barrett EG, Cox JM, Birch SM, Martinelli R, Sperber HS, Franz S, Duff T, Hoffmann M, Healy AM, Oscarson S, Pöhlmann S, Pillai SK, Simmons G, Fahy JV. Khanna K, et al. Among authors: healy am. Am J Physiol Lung Cell Mol Physiol. 2022 Sep 1;323(3):L372-L389. doi: 10.1152/ajplung.00136.2022. Epub 2022 Jun 28. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35762590 Free PMC article.
178 results