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RO6807936 as a novel positron emission tomography (PET) radiotracer for in vitro and in vivo visualization and quantification of beta-site amyloid precursor protein cleaving enzyme (BACE1) in the rodent and baboon brain.
Honer M, Polara A, Kuwabara H, Jacobsen H, Pähler A, Hartung T, Caruso A, Esterhazy D, Stoffel M, Dannals RF, Wong DF, Borroni E, Gobbi LC. Honer M, et al. Among authors: caruso a. J Labelled Comp Radiopharm. 2023 Jul;66(9):222-236. doi: 10.1002/jlcr.4025. Epub 2023 May 11. J Labelled Comp Radiopharm. 2023. PMID: 37095603
A Highly Potent, Orally Bioavailable Pyrazole-Derived Cannabinoid CB2 Receptor- Selective Full Agonist for In Vivo Studies.
Chicca A, Bátora D, Ullmer C, Caruso A, Grüner S, Fingerle J, Hartung T, Degen R, Müller M, Grether U, Pacher P, Gertsch J. Chicca A, et al. Among authors: caruso a. ACS Pharmacol Transl Sci. 2024 Jul 9;7(8):2424-2438. doi: 10.1021/acsptsci.4c00269. eCollection 2024 Aug 9. ACS Pharmacol Transl Sci. 2024. PMID: 39144568 Free article.
A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for in vivo studies.
Chicca A, Batora D, Ullmer C, Caruso A, Fingerle J, Hartung T, Degen R, Müller M, Grether U, Pacher P, Gertsch J. Chicca A, et al. Among authors: caruso a. bioRxiv [Preprint]. 2024 Apr 29:2024.04.26.591311. doi: 10.1101/2024.04.26.591311. bioRxiv. 2024. Update in: ACS Pharmacol Transl Sci. 2024 Jul 09;7(8):2424-2438. doi: 10.1021/acsptsci.4c00269 PMID: 38903103 Free PMC article. Updated. Preprint.
RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models.
Grether U, Foxton RH, Gruener S, Korn C, Kimbara A, Osterwald A, Zirwes E, Uhles S, Thoele J, Colé N, Rogers-Evans M, Röver S, Nettekoven M, Martin RE, Adam JM, Fingerle J, Bissantz C, Guba W, Alker A, Szczesniak AM, Porter RF, Toguri TJ, Revelant F, Poirier A, Perret C, Winther L, Caruso A, Fezza F, Maccarrone M, Kelly MEM, Fauser S, Ullmer C. Grether U, et al. Among authors: caruso a. Front Pharmacol. 2024 Jul 12;15:1426446. doi: 10.3389/fphar.2024.1426446. eCollection 2024. Front Pharmacol. 2024. PMID: 39070793 Free PMC article.
Translating pharmacology models effectively to predict therapeutic benefit.
Dudal S, Bissantz C, Caruso A, David-Pierson P, Driessen W, Koller E, Krippendorff BF, Lechmann M, Olivares-Morales A, Paehler A, Rynn C, Türck D, Van De Vyver A, Wang K, Winther L. Dudal S, et al. Among authors: caruso a. Drug Discov Today. 2022 Jun;27(6):1604-1621. doi: 10.1016/j.drudis.2022.03.009. Epub 2022 Mar 15. Drug Discov Today. 2022. PMID: 35304340 Free article. Review.
1,344 results