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A CREB-mediated increase in miRNA let-7f during prolonged β-agonist exposure: a novel mechanism of β2-adrenergic receptor down-regulation in airway smooth muscle.
Kim D, Cho S, Woo JA, Liggett SB. Kim D, et al. FASEB J. 2018 Jul;32(7):3680-3688. doi: 10.1096/fj.201701278R. Epub 2018 Feb 13. FASEB J. 2018. PMID: 29455573 Free PMC article.
This mechanism is apparent in asthmatic HASM cells, indicating relevance in a disease model.-Kim, D., Cho, S., Woo, J. A., Liggett, S. B. A CREB-mediated increase in miRNA let-7f during prolonged beta-agonist exposure: a novel mechanism of beta(2)-adrenergic recepto …
This mechanism is apparent in asthmatic HASM cells, indicating relevance in a disease model.-Kim, D., Cho, S., Woo, J. A., Lig …
Differential long-term regulation of TAS2R14 by structurally distinct agonists.
Woo JA, Castaño M, Goss A, Kim D, Lewandowski EM, Chen Y, Liggett SB. Woo JA, et al. Among authors: kim d. FASEB J. 2019 Nov;33(11):12213-12225. doi: 10.1096/fj.201802627RR. Epub 2019 Aug 20. FASEB J. 2019. PMID: 31430434 Free PMC article.
However, by manipulating the agonist structure, biasing toward G-protein coupling but away from long-term down-regulation can be achieved.-Woo, J. A., Castano, M., Goss, A., Kim, D., Lewandowski, E. M., Chen, Y., Liggett, S. B. Differential long-term regulation of T …
However, by manipulating the agonist structure, biasing toward G-protein coupling but away from long-term down-regulation can be achieved.-W …
The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR.
Huang J, Lam H, Koziol-White C, Limjunyawong N, Kim D, Kim N, Karmacharya N, Rajkumar P, Firer D, Dalesio NM, Jude J, Kurten RC, Pluznick JL, Deshpande DA, Penn RB, Liggett SB, Panettieri RA Jr, Dong X, An SS. Huang J, et al. Among authors: kim d, kim n. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28485-28495. doi: 10.1073/pnas.2003111117. Epub 2020 Oct 23. Proc Natl Acad Sci U S A. 2020. PMID: 33097666 Free PMC article.
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