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Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer.
Zhao J, DiGiacomo V, Ferreras-Gutierrez M, Dastjerdi S, Ibáñez de Opakua A, Park JC, Luebbers A, Chen Q, Beeler A, Blanco FJ, Garcia-Marcos M. Zhao J, et al. Among authors: blanco fj. Proc Natl Acad Sci U S A. 2023 May 2;120(18):e2213140120. doi: 10.1073/pnas.2213140120. Epub 2023 Apr 25. Proc Natl Acad Sci U S A. 2023. PMID: 37098067 Free PMC article.
Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.
de Opakua AI, Parag-Sharma K, DiGiacomo V, Merino N, Leyme A, Marivin A, Villate M, Nguyen LT, de la Cruz-Morcillo MA, Blanco-Canosa JB, Ramachandran S, Baillie GS, Cerione RA, Blanco FJ, Garcia-Marcos M. de Opakua AI, et al. Among authors: blanco canosa jb, blanco fj. Nat Commun. 2017 May 18;8:15163. doi: 10.1038/ncomms15163. Nat Commun. 2017. PMID: 28516903 Free PMC article.
The Gαi-GIV binding interface is a druggable protein-protein interaction.
DiGiacomo V, de Opakua AI, Papakonstantinou MP, Nguyen LT, Merino N, Blanco-Canosa JB, Blanco FJ, Garcia-Marcos M. DiGiacomo V, et al. Among authors: blanco canosa jb, blanco fj. Sci Rep. 2017 Aug 17;7(1):8575. doi: 10.1038/s41598-017-08829-7. Sci Rep. 2017. PMID: 28819150 Free PMC article.
Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer.
Tapia-Galisteo A, Sánchez Rodríguez Í, Aguilar-Sopeña O, Harwood SL, Narbona J, Ferreras Gutierrez M, Navarro R, Martín-García L, Corbacho C, Compte M, Lacadena J, Blanco FJ, Chames P, Roda-Navarro P, Álvarez-Vallina L, Sanz L. Tapia-Galisteo A, et al. Among authors: blanco fj. Oncoimmunology. 2022 Feb 7;11(1):2034355. doi: 10.1080/2162402X.2022.2034355. eCollection 2022. Oncoimmunology. 2022. PMID: 35154908 Free PMC article.
A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response.
Rubio-Pérez L, Lázaro-Gorines R, Harwood SL, Compte M, Navarro R, Tapia-Galisteo A, Bonet J, Blanco B, Lykkemark S, Ramírez-Fernández Á, Ferreras-Gutiérrez M, Domínguez-Alonso C, Díez-Alonso L, Segura-Tudela A, Hangiu O, Erce-Llamazares A, Blanco FJ, Santos C, Rodríguez-Peralto JL, Sanz L, Álvarez-Vallina L. Rubio-Pérez L, et al. Among authors: blanco b, blanco fj. Oncoimmunology. 2023 Apr 24;12(1):2205336. doi: 10.1080/2162402X.2023.2205336. eCollection 2023. Oncoimmunology. 2023. PMID: 37114242 Free PMC article.
Structural analysis of ING3 protein and histone H3 binding.
Ferreras-Gutiérrez M, Chaves-Arquero B, González-Magaña A, Merino N, Amusategui-Mateu I, Huecas S, Medrano FJ, Blanco FJ. Ferreras-Gutiérrez M, et al. Among authors: blanco fj. Int J Biol Macromol. 2023 Jul 1;242(Pt 1):124724. doi: 10.1016/j.ijbiomac.2023.124724. Epub 2023 May 4. Int J Biol Macromol. 2023. PMID: 37148949 Free article.
525 results