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De novo design of protein interactions with learned surface fingerprints.
Gainza P, Wehrle S, Van Hall-Beauvais A, Marchand A, Scheck A, Harteveld Z, Buckley S, Ni D, Tan S, Sverrisson F, Goverde C, Turelli P, Raclot C, Teslenko A, Pacesa M, Rosset S, Georgeon S, Marsden J, Petruzzella A, Liu K, Xu Z, Chai Y, Han P, Gao GF, Oricchio E, Fierz B, Trono D, Stahlberg H, Bronstein M, Correia BE. Gainza P, et al. Among authors: chai y. Nature. 2023 May;617(7959):176-184. doi: 10.1038/s41586-023-05993-x. Epub 2023 Apr 26. Nature. 2023. PMID: 37100904 Free PMC article.
Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy.
Liu K, Tan S, Chai Y, Chen D, Song H, Zhang CW, Shi Y, Liu J, Tan W, Lyu J, Gao S, Yan J, Qi J, Gao GF. Liu K, et al. Among authors: chai y. Cell Res. 2017 Jan;27(1):151-153. doi: 10.1038/cr.2016.102. Epub 2016 Aug 30. Cell Res. 2017. PMID: 27573173 Free PMC article. No abstract available.
An unexpected N-terminal loop in PD-1 dominates binding by nivolumab.
Tan S, Zhang H, Chai Y, Song H, Tong Z, Wang Q, Qi J, Wong G, Zhu X, Liu WJ, Gao S, Wang Z, Shi Y, Yang F, Gao GF, Yan J. Tan S, et al. Among authors: chai y. Nat Commun. 2017 Feb 6;8:14369. doi: 10.1038/ncomms14369. Nat Commun. 2017. PMID: 28165004 Free PMC article.
4,331 results