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Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis.
Amin A, Badenes M, Tüshaus J, de Carvalho É, Burbridge E, Faísca P, Trávníčková K, Barros A, Carobbio S, Domingos PM, Vidal-Puig A, Moita LF, Maguire S, Stříšovský K, Ortega FJ, Fernández-Real JM, Lichtenthaler SF, Adrain C. Amin A, et al. Among authors: adrain c. Mol Metab. 2023 Jul;73:101731. doi: 10.1016/j.molmet.2023.101731. Epub 2023 Apr 28. Mol Metab. 2023. PMID: 37121509 Free PMC article.
Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil.
Chatterjee S, Naeli P, Onar O, Simms N, Garzia A, Hackett A, Coyle K, Harris Snell P, McGirr T, Sawant TN, Dang K, Stoichkova ZV, Azam Y, Saunders MP, Braun M, Alain T, Tuschl T, McDade SS, Longley DB, Gkogkas CG, Adrain C, Knight JRP, Jafarnejad SM. Chatterjee S, et al. Among authors: adrain c. Nucleic Acids Res. 2024 Nov 11;52(20):12534-12548. doi: 10.1093/nar/gkae849. Nucleic Acids Res. 2024. PMID: 39351862 Free PMC article.
Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity.
Bläsius K, Ludwig L, Knapp S, Flaßhove C, Sonnabend F, Keller D, Tacken N, Gao X, Kahveci-Türköz S, Grannemann C, Babendreyer A, Adrain C, Huth S, Baron JM, Ludwig A, Düsterhöft S. Bläsius K, et al. Among authors: adrain c. Cell Mol Life Sci. 2024 Feb 27;81(1):102. doi: 10.1007/s00018-024-05132-3. Cell Mol Life Sci. 2024. PMID: 38409522 Free PMC article.
Mitochondria shed their outer membrane in response to infection-induced stress.
Li X, Straub J, Medeiros TC, Mehra C, den Brave F, Peker E, Atanassov I, Stillger K, Michaelis JB, Burbridge E, Adrain C, Münch C, Riemer J, Becker T, Pernas LF. Li X, et al. Among authors: adrain c. Science. 2022 Jan 14;375(6577):eabi4343. doi: 10.1126/science.abi4343. Epub 2022 Jan 14. Science. 2022. PMID: 35025629
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