Murphy ME - Search Results

1

An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.

Indeglia A, Leung JC, Miller SA, Leu JI, Dougherty JF, Clarke NL, Kirven NA, Shao C, Ke L, Lovell S, Barnoud T, Lu DY, Lin C, Kannan T, Battaile KP, Yang THL, Batista Oliva I, Claiborne DT, Vogel P, Liu L, Liu Q, Nefedova Y, Cassel J, Auslander N, Kossenkov AV, Karanicolas J, Murphy ME. Indeglia A, et al. Among authors: murphy me. Cancer Discov. 2023 Jul 7;13(7):1696-1719. doi: 10.1158/2159-8290.CD-22-1315. Cancer Discov. 2023. PMID: 37140445 Free PMC article.

2

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential.

Dumont P, Leu JI, Della Pietra AC 3rd, George DL, Murphy M. Dumont P, et al. Nat Genet. 2003 Mar;33(3):357-65. doi: 10.1038/ng1093. Epub 2003 Feb 3. Nat Genet. 2003. PMID: 12567188

3

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

Leu JI, Dumont P, Hafey M, Murphy ME, George DL. Leu JI, et al. Among authors: murphy me. Nat Cell Biol. 2004 May;6(5):443-50. doi: 10.1038/ncb1123. Epub 2004 Apr 11. Nat Cell Biol. 2004. PMID: 15077116

4

p53 moves to mitochondria: a turn on the path to apoptosis.

Murphy ME, Leu JI, George DL. Murphy ME, et al. Cell Cycle. 2004 Jul;3(7):836-9. Epub 2004 Jul 4. Cell Cycle. 2004. PMID: 15190209 Review.

5

The tetramerization domain of p53 is required for efficient BAK oligomerization.

Pietsch EC, Leu JI, Frank A, Dumont P, George DL, Murphy ME. Pietsch EC, et al. Among authors: murphy me. Cancer Biol Ther. 2007 Oct;6(10):1576-83. doi: 10.4161/cbt.6.10.4719. Epub 2007 Jul 10. Cancer Biol Ther. 2007. PMID: 17895645 Free article.

6

A small molecule inhibitor of inducible heat shock protein 70.

Leu JI, Pimkina J, Frank A, Murphy ME, George DL. Leu JI, et al. Among authors: murphy me. Mol Cell. 2009 Oct 9;36(1):15-27. doi: 10.1016/j.molcel.2009.09.023. Mol Cell. 2009. PMID: 19818706 Free PMC article.

7

The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation.

Frank AK, Leu JI, Zhou Y, Devarajan K, Nedelko T, Klein-Szanto A, Hollstein M, Murphy ME. Frank AK, et al. Among authors: murphy me. Mol Cell Biol. 2011 Mar;31(6):1201-13. doi: 10.1128/MCB.01136-10. Epub 2011 Jan 18. Mol Cell Biol. 2011. PMID: 21245379 Free PMC article.

8

HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.

Leu JI, Pimkina J, Pandey P, Murphy ME, George DL. Leu JI, et al. Among authors: murphy me. Mol Cancer Res. 2011 Jul;9(7):936-47. doi: 10.1158/1541-7786.MCR-11-0019. Epub 2011 Jun 2. Mol Cancer Res. 2011. PMID: 21636681 Free PMC article.

9

A modified HSP70 inhibitor shows broad activity as an anticancer agent.

Balaburski GM, Leu JI, Beeharry N, Hayik S, Andrake MD, Zhang G, Herlyn M, Villanueva J, Dunbrack RL Jr, Yen T, George DL, Murphy ME. Balaburski GM, et al. Among authors: murphy me. Mol Cancer Res. 2013 Mar;11(3):219-29. doi: 10.1158/1541-7786.MCR-12-0547-T. Epub 2013 Jan 9. Mol Cancer Res. 2013. PMID: 23303345 Free PMC article.

10

The p53 Codon 72 Polymorphism Modifies the Cellular Response to Inflammatory Challenge in the Liver.

Leu JI, Murphy ME, George DL. Leu JI, et al. Among authors: murphy me. J Liver. 2013;2(1):117. doi: 10.4172/2167-0889.1000117. J Liver. 2013. PMID: 23991369 Free PMC article.

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