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AI-based histologic scoring enables automated and reproducible assessment of enrollment criteria and endpoints in NASH clinical trials.
Iyer JS, Pokkalla H, Biddle-Snead C, Carrasco-Zevallos O, Lin M, Shanis Z, Le Q, Juyal D, Pouryahya M, Pedawi A, Hoffman S, Elliott H, Leidal K, Myers RP, Chung C, Billin AN, Watkins TR, Resnick M, Wack K, Glickman J, Burt AD, Loomba R, Sanyal AJ, Montalto MC, Beck AH, Taylor-Weiner A, Wapinski I. Iyer JS, et al. Among authors: leidal k. medRxiv [Preprint]. 2023 Apr 25:2023.04.20.23288534. doi: 10.1101/2023.04.20.23288534. medRxiv. 2023. PMID: 37162870 Free PMC article. Preprint.
AI powered quantification of nuclear morphology in cancers enables prediction of genome instability and prognosis.
Abel J, Jain S, Rajan D, Padigela H, Leidal K, Prakash A, Conway J, Nercessian M, Kirkup C, Javed SA, Biju R, Harguindeguy N, Shenker D, Indorf N, Sanghavi D, Egger R, Trotter B, Gerardin Y, Brosnan-Cashman JA, Dhoot A, Montalto MC, Parmar C, Wapinski I, Khosla A, Drage MG, Yu L, Taylor-Weiner A. Abel J, et al. Among authors: leidal k. NPJ Precis Oncol. 2024 Jun 19;8(1):134. doi: 10.1038/s41698-024-00623-9. NPJ Precis Oncol. 2024. PMID: 38898127 Free PMC article.
AI-based automation of enrollment criteria and endpoint assessment in clinical trials in liver diseases.
Iyer JS, Juyal D, Le Q, Shanis Z, Pokkalla H, Pouryahya M, Pedawi A, Stanford-Moore SA, Biddle-Snead C, Carrasco-Zevallos O, Lin M, Egger R, Hoffman S, Elliott H, Leidal K, Myers RP, Chung C, Billin AN, Watkins TR, Patterson SD, Resnick M, Wack K, Glickman J, Burt AD, Loomba R, Sanyal AJ, Glass B, Montalto MC, Taylor-Weiner A, Wapinski I, Beck AH. Iyer JS, et al. Among authors: leidal k. Nat Med. 2024 Oct;30(10):2914-2923. doi: 10.1038/s41591-024-03172-7. Epub 2024 Aug 7. Nat Med. 2024. PMID: 39112795 Free PMC article.
Boltz-1 Democratizing Biomolecular Interaction Modeling.
Wohlwend J, Corso G, Passaro S, Reveiz M, Leidal K, Swiderski W, Portnoi T, Chinn I, Silterra J, Jaakkola T, Barzilay R. Wohlwend J, et al. Among authors: leidal k. bioRxiv [Preprint]. 2024 Nov 20:2024.11.19.624167. doi: 10.1101/2024.11.19.624167. bioRxiv. 2024. PMID: 39605745 Free PMC article. Preprint.
Cathepsin G Degrades Staphylococcus aureus Biofilms.
Kavanaugh JS, Leidal KG, Nauseef WM, Horswill AR. Kavanaugh JS, et al. Among authors: leidal kg. J Infect Dis. 2021 Jun 4;223(11):1865-1869. doi: 10.1093/infdis/jiaa612. J Infect Dis. 2021. PMID: 32995850 Free PMC article.
NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action.
Jaquet V, Marcoux J, Forest E, Leidal KG, McCormick S, Westermaier Y, Perozzo R, Plastre O, Fioraso-Cartier L, Diebold B, Scapozza L, Nauseef WM, Fieschi F, Krause KH, Bedard K. Jaquet V, et al. Among authors: leidal kg. Br J Pharmacol. 2011 Sep;164(2b):507-20. doi: 10.1111/j.1476-5381.2011.01439.x. Br J Pharmacol. 2011. PMID: 21501142 Free PMC article.
33 results