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Activation of human STING by a molecular glue-like compound.
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y. Li J, et al. Among authors: tallarico ja. Nat Chem Biol. 2024 Mar;20(3):365-372. doi: 10.1038/s41589-023-01434-y. Epub 2023 Oct 12. Nat Chem Biol. 2024. PMID: 37828400 Free PMC article.
Correction to "Rational Chemical Design of Molecular Glue Degraders".
Toriki ES, Papatzimas JW, Nishikawa K, Dovala D, Frank AO, Hesse MJ, Dankova D, Song JG, Bruce-Smythe M, Struble H, Garcia FJ, Brittain SM, Kile AC, McGregor LM, McKenna JM, Tallarico JA, Schirle M, Nomura DK. Toriki ES, et al. Among authors: tallarico ja. ACS Cent Sci. 2023 Jul 21;9(8):1702. doi: 10.1021/acscentsci.3c00844. eCollection 2023 Aug 23. ACS Cent Sci. 2023. PMID: 37637749 Free PMC article.
Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction.
Ding J, Liu L, Chiang YL, Zhao M, Liu H, Yang F, Shen L, Lin Y, Deng H, Gao J, Sage DR, West L, Llamas LA, Hao X, Kawatkar S, Li E, Jain RK, Tallarico JA, Canham SM, Wang H. Ding J, et al. Among authors: tallarico ja. J Med Chem. 2023 Jun 22;66(12):8310-8323. doi: 10.1021/acs.jmedchem.3c00787. Epub 2023 Jun 12. J Med Chem. 2023. PMID: 37307526
Rational Chemical Design of Molecular Glue Degraders.
Toriki ES, Papatzimas JW, Nishikawa K, Dovala D, Frank AO, Hesse MJ, Dankova D, Song JG, Bruce-Smythe M, Struble H, Garcia FJ, Brittain SM, Kile AC, McGregor LM, McKenna JM, Tallarico JA, Schirle M, Nomura DK. Toriki ES, et al. Among authors: tallarico ja. ACS Cent Sci. 2023 Apr 11;9(5):915-926. doi: 10.1021/acscentsci.2c01317. eCollection 2023 May 24. ACS Cent Sci. 2023. PMID: 37252349 Free PMC article.
Accelerating antiviral drug discovery: lessons from COVID-19.
von Delft A, Hall MD, Kwong AD, Purcell LA, Saikatendu KS, Schmitz U, Tallarico JA, Lee AA. von Delft A, et al. Among authors: tallarico ja. Nat Rev Drug Discov. 2023 Jul;22(7):585-603. doi: 10.1038/s41573-023-00692-8. Epub 2023 May 12. Nat Rev Drug Discov. 2023. PMID: 37173515 Free PMC article. Review.
Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors.
Moon P, Zammit CM, Shao Q, Dovala D, Boike L, Henning NJ, Knapp M, Spradlin JN, Ward CC, Wolleb H, Fuller D, Blake G, Murphy JP, Wang F, Lu Y, Moquin SA, Tandeske L, Hesse MJ, McKenna JM, Tallarico JA, Schirle M, Toste FD, Nomura DK. Moon P, et al. Among authors: tallarico ja. Chembiochem. 2023 Jun 1;24(11):e202300116. doi: 10.1002/cbic.202300116. Epub 2023 May 3. Chembiochem. 2023. PMID: 37069799
Ophiobolin A Covalently Targets Complex IV Leading to Mitochondrial Metabolic Collapse in Cancer Cells.
Gowans FA, Thach DQ, Wang Y, Altamirano Poblano BE, Dovala D, Tallarico JA, McKenna JM, Schirle M, Maimone TJ, Nomura DK. Gowans FA, et al. Among authors: tallarico ja. bioRxiv [Preprint]. 2023 Mar 9:2023.03.09.531918. doi: 10.1101/2023.03.09.531918. bioRxiv. 2023. Update in: ACS Chem Biol. 2024 Jun 21;19(6):1260-1270. doi: 10.1021/acschembio.4c00064 PMID: 36945520 Free PMC article. Updated. Preprint.
58 results