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Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis.
Chour W, Choi J, Xie J, Chaffee ME, Schmitt TM, Finton K, DeLucia DC, Xu AM, Su Y, Chen DG, Zhang R, Yuan D, Hong S, Ng AHC, Butler JZ, Edmark RA, Jones LC, Murray KM, Peng S, Li G, Strong RK, Lee JK, Goldman JD, Greenberg PD, Heath JR. Chour W, et al. Among authors: heath jr. Commun Biol. 2023 May 16;6(1):528. doi: 10.1038/s42003-023-04899-8. Commun Biol. 2023. PMID: 37193826 Free PMC article.
A kinetic investigation of interacting, stimulated T cells identifies conditions for rapid functional enhancement, minimal phenotype differentiation, and improved adoptive cell transfer tumor eradication.
Zhou J, Bethune MT, Malkova N, Sutherland AM, Comin-Anduix B, Su Y, Baltimore D, Ribas A, Heath JR. Zhou J, et al. Among authors: heath jr. PLoS One. 2018 Jan 23;13(1):e0191634. doi: 10.1371/journal.pone.0191634. eCollection 2018. PLoS One. 2018. PMID: 29360859 Free PMC article.
T cell antigen discovery via signaling and antigen-presenting bifunctional receptors.
Joglekar AV, Leonard MT, Jeppson JD, Swift M, Li G, Wong S, Peng S, Zaretsky JM, Heath JR, Ribas A, Bethune MT, Baltimore D. Joglekar AV, et al. Among authors: heath jr. Nat Methods. 2019 Feb;16(2):191-198. doi: 10.1038/s41592-018-0304-8. Epub 2019 Jan 28. Nat Methods. 2019. PMID: 30700902 Free PMC article.
T cell antigen discovery via trogocytosis.
Li G, Bethune MT, Wong S, Joglekar AV, Leonard MT, Wang JK, Kim JT, Cheng D, Peng S, Zaretsky JM, Su Y, Luo Y, Heath JR, Ribas A, Witte ON, Baltimore D. Li G, et al. Among authors: heath jr. Nat Methods. 2019 Feb;16(2):183-190. doi: 10.1038/s41592-018-0305-7. Epub 2019 Jan 28. Nat Methods. 2019. PMID: 30700903 Free PMC article.
Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood.
Peng S, Zaretsky JM, Ng AHC, Chour W, Bethune MT, Choi J, Hsu A, Holman E, Ding X, Guo K, Kim J, Xu AM, Heath JE, Noh WJ, Zhou J, Su Y, Lu Y, McLaughlin J, Cheng D, Witte ON, Baltimore D, Ribas A, Heath JR. Peng S, et al. Among authors: heath jr, heath je. Cell Rep. 2019 Sep 3;28(10):2728-2738.e7. doi: 10.1016/j.celrep.2019.07.106. Cell Rep. 2019. PMID: 31484081 Free PMC article.
475 results