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Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: results from the WILLOW trial.
Cipolla D, Zhang J, Korkmaz B, Chalmers JD, Basso J, Lasala D, Fernandez C, Teper A, Mange KC, Perkins WR, Sullivan EJ. Cipolla D, et al. Among authors: lasala d. Respir Res. 2023 May 17;24(1):133. doi: 10.1186/s12931-023-02444-z. Respir Res. 2023. PMID: 37198686 Free PMC article. Clinical Trial.
The pharmacokinetic profile of brensocatib and its effect on pharmacodynamic biomarkers including NE, PR3, and CatG in various rodent species.
Basso J, Chen KJ, Zhou Y, Mark L, LaSala D, Dorfman A, Atalla M, Chun D, Viramontes V, Chang C, Leifer F, McDonald PP, Cipolla DC. Basso J, et al. Among authors: lasala d. Front Pharmacol. 2023 Jul 19;14:1208780. doi: 10.3389/fphar.2023.1208780. eCollection 2023. Front Pharmacol. 2023. PMID: 37538173 Free PMC article.
Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells.
Sutton VR, Watt SV, Akhlaghi H, Cipolla DC, Chen KJ, LaSala D, McDonald PP, Beavis PA, Munoz I, Hodel AW, Noori T, Voskoboinik I, Trapani JA. Sutton VR, et al. Among authors: lasala d. Front Pharmacol. 2024 Jul 3;15:1396710. doi: 10.3389/fphar.2024.1396710. eCollection 2024. Front Pharmacol. 2024. PMID: 39021839 Free PMC article.
Correction for Plaunt et al., "Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections".
Plaunt AJ, Rose SJ, Kang JY, Chen KJ, LaSala D, Heckler RP, Dorfman A, Smith BT, Chun D, Viramontes V, Macaluso A, Li Z, Zhou Y, Mark L, Basso J, Leifer FG, Corboz MR, Chapman RW, Cipolla D, Perkins WR, Malinin VS, Konicek DM. Plaunt AJ, et al. Among authors: lasala d. Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0125622. doi: 10.1128/aac.01256-22. Epub 2022 Oct 12. Antimicrob Agents Chemother. 2022. PMID: 36222535 Free PMC article. No abstract available.
Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections.
Plaunt AJ, Rose SJ, Kang JY, Chen KJ, LaSala D, Heckler RP, Dorfman A, Smith BT, Chun D, Viramontes V, Macaluso A, Li Z, Zhou Y, Mark L, Basso J, Leifer FG, Corboz MR, Chapman RW, Cipolla D, Perkins WR, Malinin VS, Konicek DM. Plaunt AJ, et al. Among authors: lasala d. Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0031621. doi: 10.1128/AAC.00316-21. Epub 2021 Jun 17. Antimicrob Agents Chemother. 2021. PMID: 33941518 Free PMC article.
Prostanoid receptor subtypes involved in treprostinil-mediated vasodilation of rat pulmonary arteries and in treprostinil-mediated inhibition of collagen gene expression of human lung fibroblasts.
Corboz MR, Salvail W, Gagnon S, LaSala D, Laurent CE, Salvail D, Chen KJ, Cipolla D, Perkins WR, Chapman RW. Corboz MR, et al. Among authors: lasala d. Prostaglandins Other Lipid Mediat. 2021 Feb;152:106486. doi: 10.1016/j.prostaglandins.2020.106486. Epub 2020 Oct 1. Prostaglandins Other Lipid Mediat. 2021. PMID: 33011365 Free article.
23 results