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Feasibility and value of genomic profiling in cancer of unknown primary: real-world evidence from prospective profiling study.
Huey RW, Shah AT, Reddi HV, Dasari P, Topham JT, Hwang H, Dhillon N, Willett A, Smaglo BG, Estrella JS, Rashid A, Matamoros A, Overman MJ, Choquette L, Omerza G, Kelly K, Wang X, Loree JM, Rueter J, Varadhachary GR, Raghav K. Huey RW, et al. Among authors: topham jt. J Natl Cancer Inst. 2023 Aug 8;115(8):994-997. doi: 10.1093/jnci/djad095. J Natl Cancer Inst. 2023. PMID: 37202363 Free PMC article. Clinical Trial.
Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration.
Chun HE, Johann PD, Milne K, Zapatka M, Buellesbach A, Ishaque N, Iskar M, Erkek S, Wei L, Tessier-Cloutier B, Lever J, Titmuss E, Topham JT, Bowlby R, Chuah E, Mungall KL, Ma Y, Mungall AJ, Moore RA, Taylor MD, Gerhard DS, Jones SJM, Korshunov A, Gessler M, Kerl K, Hasselblatt M, Frühwald MC, Perlman EJ, Nelson BH, Pfister SM, Marra MA, Kool M. Chun HE, et al. Among authors: topham jt. Cell Rep. 2019 Nov 19;29(8):2338-2354.e7. doi: 10.1016/j.celrep.2019.10.013. Epub 2019 Nov 7. Cell Rep. 2019. PMID: 31708418 Free PMC article.
Integration of Whole-Genome Sequencing With Circulating Tumor DNA Analysis Captures Clonal Evolution and Tumor Heterogeneity in Non-V600 BRAF Mutant Colorectal Cancer.
Mendis S, Alcaide M, Topham JT, Johnson B, Morin RD, Chu J, Bosdet I, Kopetz S, Karsan A, Gill S, Laskin J, Jones SJM, Marra MA, Schaeffer DF, Renouf DJ, Loree JM. Mendis S, et al. Among authors: topham jt. Clin Colorectal Cancer. 2020 Jun;19(2):132-136.e3. doi: 10.1016/j.clcc.2020.02.001. Epub 2020 Feb 10. Clin Colorectal Cancer. 2020. PMID: 32151517 No abstract available.
Endogenous Retrovirus Transcript Levels Are Associated with Immunogenic Signatures in Multiple Metastatic Cancer Types.
Topham JT, Titmuss E, Pleasance ED, Williamson LM, Karasinska JM, Culibrk L, Lee MKC, Mendis S, Denroche RE, Jang GH, Kalloger SE, Wong HL, Moore RA, Mungall AJ, O'Kane GM, Knox JJ, Gallinger S, Loree JM, Mager DL, Laskin J, Marra MA, Jones SJM, Schaeffer DF, Renouf DJ. Topham JT, et al. Mol Cancer Ther. 2020 Sep;19(9):1889-1897. doi: 10.1158/1535-7163.MCT-20-0094. Epub 2020 Jun 9. Mol Cancer Ther. 2020. PMID: 32518206
Delving into Early-onset Pancreatic Ductal Adenocarcinoma: How Does Age Fit In?
Tsang ES, Topham JT, Karasinska JM, Lee MKC, Williamson LM, Mendis S, Denroche RE, Jang GH, Kalloger SE, Moore RA, Mungall AJ, Bathe OF, Tang PA, Notta F, Wilson JM, Laskin J, O'Kane GM, Knox JJ, Goodwin RA, Loree JM, Jones SJM, Marra MA, Gallinger S, Schaeffer DF, Renouf DJ. Tsang ES, et al. Among authors: topham jt. Clin Cancer Res. 2021 Jan 1;27(1):246-254. doi: 10.1158/1078-0432.CCR-20-1042. Epub 2020 Sep 21. Clin Cancer Res. 2021. PMID: 32958704
Subtype-Discordant Pancreatic Ductal Adenocarcinoma Tumors Show Intermediate Clinical and Molecular Characteristics.
Topham JT, Karasinska JM, Lee MKC, Csizmok V, Williamson LM, Jang GH, Denroche RE, Tsang ES, Kalloger SE, Wong HL, O'Kane GM, Moore RA, Mungall AJ, Notta F, Loree JM, Wilson JM, Bathe O, Tang PA, Goodwin R, Knox JJ, Gallinger S, Laskin J, Marra MA, Jones SJM, Renouf DJ, Schaeffer DF. Topham JT, et al. Clin Cancer Res. 2021 Jan 1;27(1):150-157. doi: 10.1158/1078-0432.CCR-20-2831. Epub 2020 Oct 13. Clin Cancer Res. 2021. PMID: 33051307
Uncovering Clinically Relevant Gene Fusions with Integrated Genomic and Transcriptomic Profiling of Metastatic Cancers.
Tsang ES, Grisdale CJ, Pleasance E, Topham JT, Mungall K, Reisle C, Choo C, Carreira M, Bowlby R, Karasinska JM, MacMillan D, Williamson LM, Chuah E, Moore RA, Mungall AJ, Zhao Y, Tessier-Cloutier B, Ng T, Sun S, Lim HJ, Schaeffer DF, Renouf DJ, Yip S, Laskin J, Marra MA, Jones SJM, Loree JM. Tsang ES, et al. Among authors: topham jt. Clin Cancer Res. 2021 Jan 15;27(2):522-531. doi: 10.1158/1078-0432.CCR-20-1900. Epub 2020 Nov 4. Clin Cancer Res. 2021. PMID: 33148671
The Neoantigen Landscape of the Coding and Noncoding Cancer Genome Space.
Lau TTY, Sefid Dashti ZJ, Titmuss E, Pender A, Topham JT, Bridgers J, Loree JM, Feng X, Pleasance ED, Renouf DJ, Schrader KA, Sun S, Ho C, Marra MA, Laskin J, Karsan A. Lau TTY, et al. Among authors: topham jt. J Mol Diagn. 2022 Jun;24(6):609-618. doi: 10.1016/j.jmoldx.2022.02.004. Epub 2022 Mar 31. J Mol Diagn. 2022. PMID: 35367630 Free article.
The CCTG PA.7 phase II trial of gemcitabine and nab-paclitaxel with or without durvalumab and tremelimumab as initial therapy in metastatic pancreatic ductal adenocarcinoma.
Renouf DJ, Loree JM, Knox JJ, Topham JT, Kavan P, Jonker D, Welch S, Couture F, Lemay F, Tehfe M, Harb M, Aucoin N, Ko YJ, Tang PA, Ramjeesingh R, Meyers BM, Kim CA, Du P, Jia S, Schaeffer DF, Gill S, Tu D, O'Callaghan CJ. Renouf DJ, et al. Among authors: topham jt. Nat Commun. 2022 Aug 26;13(1):5020. doi: 10.1038/s41467-022-32591-8. Nat Commun. 2022. PMID: 36028483 Free PMC article. Clinical Trial.
33 results