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Tubulin Polyglutamylation by TTLL1 and TTLL7 Regulate Glutamate Concentration in the Mice Brain.
Ping Y, Ohata K, Kikushima K, Sakamoto T, Islam A, Xu L, Zhang H, Chen B, Yan J, Eto F, Nakane C, Takao K, Miyakawa T, Kabashima K, Watanabe M, Kahyo T, Yao I, Fukuda A, Ikegami K, Konishi Y, Setou M. Ping Y, et al. Among authors: ikegami k. Biomolecules. 2023 May 1;13(5):784. doi: 10.3390/biom13050784. Biomolecules. 2023. PMID: 37238654 Free PMC article.
Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function.
Ikegami K, Heier RL, Taruishi M, Takagi H, Mukai M, Shimma S, Taira S, Hatanaka K, Morone N, Yao I, Campbell PK, Yuasa S, Janke C, Macgregor GR, Setou M. Ikegami K, et al. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3213-8. doi: 10.1073/pnas.0611547104. Epub 2007 Feb 20. Proc Natl Acad Sci U S A. 2007. PMID: 17360631 Free PMC article.
Recombinant mammalian tubulin polyglutamylase TTLL7 performs both initiation and elongation of polyglutamylation on beta-tubulin through a random sequential pathway.
Mukai M, Ikegami K, Sugiura Y, Takeshita K, Nakagawa A, Setou M. Mukai M, et al. Among authors: ikegami k. Biochemistry. 2009 Feb 10;48(5):1084-93. doi: 10.1021/bi802047y. Biochemistry. 2009. PMID: 19152315
We and others have recently identified tubulin polyglutamylases in the TTLL family [Janke, C., et al. (2005) Science 308, 1758-1762; Ikegami, K., et al. (2006) J. Biol. Chem. 281, 30707-30716; van Dijk, J., et al. (2007) Mol. ...
We and others have recently identified tubulin polyglutamylases in the TTLL family [Janke, C., et al. (2005) Science 308, 1758-1762; Ikeg …
458 results