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Page 1
Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma.
Ali W, Spengler G, Kincses A, Nové M, Battistelli C, Latacz G, Starek M, Dąbrowska M, Honkisz-Orzechowska E, Romanelli A, Rasile MM, Szymańska E, Jacob C, Zwergel C, Handzlik J. Ali W, et al. Eur J Med Chem. 2020 Aug 15;200:112435. doi: 10.1016/j.ejmech.2020.112435. Epub 2020 May 15. Eur J Med Chem. 2020. PMID: 32505850
Cyanobiphenyls: Novel H3 receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer's disease.
Godyń J, Zaręba P, Łażewska D, Stary D, Reiner-Link D, Frank A, Latacz G, Mogilski S, Kaleta M, Doroz-Płonka A, Lubelska A, Honkisz-Orzechowska E, Olejarz-Maciej A, Handzlik J, Stark H, Kieć-Kononowicz K, Malawska B, Bajda M. Godyń J, et al. Bioorg Chem. 2021 Sep;114:105129. doi: 10.1016/j.bioorg.2021.105129. Epub 2021 Jun 28. Bioorg Chem. 2021. PMID: 34217977 Free article.
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT6 receptor with anti-aggregation properties against amyloid-beta and tau.
Wichur T, Pasieka A, Godyń J, Panek D, Góral I, Latacz G, Honkisz-Orzechowska E, Bucki A, Siwek A, Głuch-Lutwin M, Knez D, Brazzolotto X, Gobec S, Kołaczkowski M, Sabate R, Malawska B, Więckowska A. Wichur T, et al. Eur J Med Chem. 2021 Dec 5;225:113783. doi: 10.1016/j.ejmech.2021.113783. Epub 2021 Aug 19. Eur J Med Chem. 2021. PMID: 34461507 Free article.
The Phenoxyalkyltriazine Antagonists for 5-HT6 Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases.
Sudoł S, Cios A, Jastrzębska-Więsek M, Honkisz-Orzechowska E, Mordyl B, Wilczyńska-Zawal N, Satała G, Kucwaj-Brysz K, Partyka A, Latacz G, Olejarz-Maciej A, Wesołowska A, Handzlik J. Sudoł S, et al. Int J Mol Sci. 2021 Oct 5;22(19):10773. doi: 10.3390/ijms221910773. Int J Mol Sci. 2021. PMID: 34639113 Free PMC article.
Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma.
Ali W, Garbo S, Kincses A, Nové M, Spengler G, Di Bello E, Honkisz-Orzechowska E, Karcz T, Szymańska E, Żesławska E, Starek M, Dąbrowska M, Nitek W, Kucwaj-Brysz K, Pyka P, Fioravanti R, Jacob C, Battistelli C, Zwergel C, Handzlik J. Ali W, et al. Eur J Med Chem. 2022 Dec 5;243:114761. doi: 10.1016/j.ejmech.2022.114761. Epub 2022 Sep 19. Eur J Med Chem. 2022. PMID: 36179403
Dual Targeting Ligands-Histamine H3 Receptor Ligands with Monoamine Oxidase B Inhibitory Activity-In Vitro and In Vivo Evaluation.
Łażewska D, Siwek A, Olejarz-Maciej A, Doroz-Płonka A, Wiktorowska-Owczarek A, Jóźwiak-Bębenista M, Reiner-Link D, Frank A, Sromek-Trzaskowska W, Honkisz-Orzechowska E, Królicka E, Stark H, Wieczorek M, Wagner W, Kieć-Kononowicz K, Stasiak A. Łażewska D, et al. Pharmaceutics. 2022 Oct 13;14(10):2187. doi: 10.3390/pharmaceutics14102187. Pharmaceutics. 2022. PMID: 36297622 Free PMC article.
Anti-inflammatory effects of new human histamine H3 receptor ligands with flavonoid structure on BV-2 neuroinflammation.
Honkisz-Orzechowska E, Popiołek-Barczyk K, Linart Z, Filipek-Gorzała J, Rudnicka A, Siwek A, Werner T, Stark H, Chwastek J, Starowicz K, Kieć-Kononowicz K, Łażewska D. Honkisz-Orzechowska E, et al. Inflamm Res. 2023 Feb;72(2):181-194. doi: 10.1007/s00011-022-01658-z. Epub 2022 Nov 12. Inflamm Res. 2023. PMID: 36370200 Free PMC article.
22 results