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Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy.
Carey LM, Xu Z, Rajic G, Makriyannis A, Romero J, Hillard C, Mackie K, Hohmann AG. Carey LM, et al. Among authors: mackie k. Pharmacol Res. 2023 Jan;187:106560. doi: 10.1016/j.phrs.2022.106560. Epub 2022 Nov 20. Pharmacol Res. 2023. PMID: 36417942 Free PMC article.
Cannabinoid CB2 receptors in primary sensory neurons are implicated in CB2 agonist-mediated suppression of paclitaxel-induced neuropathic nociception and sexually-dimorphic sparing of morphine tolerance.
Guenther KG, Lin X, Xu Z, Makriyannis A, Romero J, Hillard CJ, Mackie K, Hohmann AG. Guenther KG, et al. Among authors: mackie k. Biomed Pharmacother. 2024 Jul;176:116879. doi: 10.1016/j.biopha.2024.116879. Epub 2024 Jun 7. Biomed Pharmacother. 2024. PMID: 38850666 Free PMC article.
Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors distinct from the cannabinoid CB1 and CB2 receptors.
Kline T, Xu C, Kreitzer FR, Hurst DP, Eldeeb KM, Wager-Miller J, Olivas K, Hepburn SA, Huffman JW, Mackie K, Howlett AC, Reggio P, Stella N. Kline T, et al. Among authors: mackie k. Eur J Med Chem. 2023 Mar 5;249:115123. doi: 10.1016/j.ejmech.2023.115123. Epub 2023 Jan 26. Eur J Med Chem. 2023. PMID: 36708677 Free PMC article.
479 results