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ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability.
Lee WH, Carey LM, Li LL, Xu Z, Lai YY, Courtney MJ, Hohmann AG. Lee WH, et al. Among authors: xu z. Mol Pain. 2018 Jan-Dec;14:1744806918801224. doi: 10.1177/1744806918801224. Epub 2018 Aug 29. Mol Pain. 2018. PMID: 30157705 Free PMC article.
Brain permeant and impermeant inhibitors of fatty-acid amide hydrolase suppress the development and maintenance of paclitaxel-induced neuropathic pain without producing tolerance or physical dependence in vivo and synergize with paclitaxel to reduce tumor cell line viability in vitro.
Slivicki RA, Xu Z, Mali SS, Hohmann AG. Slivicki RA, et al. Among authors: xu z. Pharmacol Res. 2019 Apr;142:267-282. doi: 10.1016/j.phrs.2019.02.002. Epub 2019 Feb 7. Pharmacol Res. 2019. PMID: 30739035 Free PMC article.
Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy.
Carey LM, Xu Z, Rajic G, Makriyannis A, Romero J, Hillard C, Mackie K, Hohmann AG. Carey LM, et al. Among authors: xu z. Pharmacol Res. 2023 Jan;187:106560. doi: 10.1016/j.phrs.2022.106560. Epub 2022 Nov 20. Pharmacol Res. 2023. PMID: 36417942 Free PMC article.
Cannabinoid CB 2 receptors in primary sensory neurons are implicated in CB 2 agonist-mediated suppression of paclitaxel-induced neuropathic nociception and sexually-dimorphic sparing of morphine tolerance.
Guenther KG, Lin X, Xu Z, Makriyannis A, Romero J, Hillard CJ, Mackie K, Hohmann AG. Guenther KG, et al. Among authors: xu z. bioRxiv [Preprint]. 2024 Mar 10:2024.03.05.583426. doi: 10.1101/2024.03.05.583426. bioRxiv. 2024. Update in: Biomed Pharmacother. 2024 Jul;176:116879. doi: 10.1016/j.biopha.2024.116879 PMID: 38496640 Free PMC article. Updated. Preprint.
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