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The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration.
Dudek M, Yang N, Ruckshanthi JP, Williams J, Borysiewicz E, Wang P, Adamson A, Li J, Bateman JF, White MR, Boot-Handford RP, Hoyland JA, Meng QJ. Dudek M, et al. Among authors: meng qj. Ann Rheum Dis. 2017 Mar;76(3):576-584. doi: 10.1136/annrheumdis-2016-209428. Epub 2016 Aug 3. Ann Rheum Dis. 2017. PMID: 27489225 Free PMC article.
Circadian control of the secretory pathway maintains collagen homeostasis.
Chang J, Garva R, Pickard A, Yeung CC, Mallikarjun V, Swift J, Holmes DF, Calverley B, Lu Y, Adamson A, Raymond-Hayling H, Jensen O, Shearer T, Meng QJ, Kadler KE. Chang J, et al. Among authors: meng qj. Nat Cell Biol. 2020 Jan;22(1):74-86. doi: 10.1038/s41556-019-0441-z. Epub 2020 Jan 6. Nat Cell Biol. 2020. PMID: 31907414 Free PMC article.
Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator.
Yang N, Smyllie NJ, Morris H, Gonçalves CF, Dudek M, Pathiranage DRJ, Chesham JE, Adamson A, Spiller DG, Zindy E, Bagnall J, Humphreys N, Hoyland J, Loudon ASI, Hastings MH, Meng QJ. Yang N, et al. Among authors: meng qj. PLoS Genet. 2020 Apr 30;16(4):e1008729. doi: 10.1371/journal.pgen.1008729. eCollection 2020 Apr. PLoS Genet. 2020. PMID: 32352975 Free PMC article.
Development of human cartilage circadian rhythm in a stem cell-chondrogenesis model.
Naven MA, Zeef LAH, Li S, Humphreys PA, Smith CA, Pathiranage D, Cain S, Woods S, Bates N, Au M, Wen C, Kimber SJ, Meng QJ. Naven MA, et al. Among authors: meng qj. Theranostics. 2022 May 13;12(8):3963-3976. doi: 10.7150/thno.70893. eCollection 2022. Theranostics. 2022. PMID: 35664072 Free PMC article.
122 results