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Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology.
Paes D, Schepers M, Willems E, Rombaut B, Tiane A, Solomina Y, Tibbo A, Blair C, Kyurkchieva E, Baillie GS, Ricciarelli R, Brullo C, Fedele E, Bruno O, van den Hove D, Vanmierlo T, Prickaerts J. Paes D, et al. Among authors: kyurkchieva e. Cell Mol Life Sci. 2023 Jun 12;80(7):178. doi: 10.1007/s00018-023-04804-w. Cell Mol Life Sci. 2023. PMID: 37306762 Free PMC article.
Short PDE4 Isoforms as Drug Targets in Disease.
Kyurkchieva E, Baillie GS. Kyurkchieva E, et al. Front Biosci (Landmark Ed). 2023 Jul 4;28(7):133. doi: 10.31083/j.fbl2807133. Front Biosci (Landmark Ed). 2023. PMID: 37525918 Free article. Review.
Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera.
Sin YY, Giblin A, Judina A, Rujirachaivej P, Corral LG, Glennon E, Tai ZX, Feng T, Torres E, Zorn A, Gorelik J, Kyurkchieva E, Yenchitsomanus PT, Swindlehurst C, Chan K, Stirling D, Baillie GS. Sin YY, et al. Among authors: kyurkchieva e. FEBS J. 2024 Dec 13. doi: 10.1111/febs.17359. Online ahead of print. FEBS J. 2024. PMID: 39673076