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Two cases of severe pulmonary toxicity from highly active mesothelin-directed CAR T cells.
Haas AR, Golden RJ, Litzky LA, Engels B, Zhao L, Xu F, Taraszka JA, Ramones M, Granda B, Chang WJ, Jadlowsky J, Shea KM, Runkle A, Chew A, Dowd E, Gonzalez V, Chen F, Liu X, Fang C, Jiang S, Davis MM, Sheppard NC, Zhao Y, Fraietta JA, Lacey SF, Plesa G, Melenhorst JJ, Mansfield K, Brogdon JL, Young RM, Albelda SM, June CH, Tanyi JL. Haas AR, et al. Among authors: sheppard nc. Mol Ther. 2023 Aug 2;31(8):2309-2325. doi: 10.1016/j.ymthe.2023.06.006. Epub 2023 Jun 12. Mol Ther. 2023. PMID: 37312454 Free PMC article.
Swiss army knife T cell: one T cell many tumor targets.
Berjis A, Muthumani D, Sheppard NC, June CH. Berjis A, et al. Among authors: sheppard nc. Cell Res. 2024 Jan;34(1):5-6. doi: 10.1038/s41422-023-00871-7. Cell Res. 2024. PMID: 37666977 Free PMC article. No abstract available.
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy.
Metzloff AE, Padilla MS, Gong N, Billingsley MM, Han X, Merolle M, Mai D, Figueroa-Espada CG, Thatte AS, Haley RM, Mukalel AJ, Hamilton AG, Alameh MG, Weissman D, Sheppard NC, June CH, Mitchell MJ. Metzloff AE, et al. Among authors: sheppard nc. Adv Mater. 2024 Jun;36(26):e2313226. doi: 10.1002/adma.202313226. Epub 2024 Mar 15. Adv Mater. 2024. PMID: 38419362
Stem Loop Mediated Transgene Modulation in Human T Cells.
Mai D, Harro C, Sanyal A, Rommel PC, Sheppard NC, June CH. Mai D, et al. Among authors: sheppard nc. ACS Synth Biol. 2024 Dec 20;13(12):3897-3907. doi: 10.1021/acssynbio.4c00152. Epub 2024 Dec 6. ACS Synth Biol. 2024. PMID: 39642942 Free PMC article.
Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice.
Hasanali ZS, Garfall AL, Burzenski L, Shultz LD, Tang Y, Kadu S, Sheppard NC, Liu W, Dopkin D, Vogl DT, Cohen AD, Waxman AJ, Susanibar-Adaniya SP, Carroll M, Stadtmauer EA, Allman D. Hasanali ZS, et al. Among authors: sheppard nc. JCI Insight. 2024 May 7;9(10):e177300. doi: 10.1172/jci.insight.177300. JCI Insight. 2024. PMID: 38713510 Free PMC article.
32 results