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Page 1
A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function.
Bahnan W, Happonen L, Khakzad H, Kumra Ahnlide V, de Neergaard T, Wrighton S, André O, Bratanis E, Tang D, Hellmark T, Björck L, Shannon O, Malmström L, Malmström J, Nordenfelt P. Bahnan W, et al. Among authors: bratanis e. EMBO Mol Med. 2023 Feb 8;15(2):e16208. doi: 10.15252/emmm.202216208. Epub 2022 Dec 12. EMBO Mol Med. 2023. PMID: 36507602 Free PMC article.
The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies.
Izadi A, Karami Y, Bratanis E, Wrighton S, Khakzad H, Nyblom M, Olofsson B, Happonen L, Tang D, Sundwall M, Godzwon M, Chao Y, Toledo AG, Schmidt T, Ohlin M, Nilges M, Malmström J, Bahnan W, Shannon O, Malmström L, Nordenfelt P. Izadi A, et al. Among authors: bratanis e. Nat Commun. 2024 Apr 27;15(1):3600. doi: 10.1038/s41467-024-47928-8. Nat Commun. 2024. PMID: 38678029 Free PMC article.