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4-Thioribose Analogues of Adenosine Diphosphate Ribose (ADPr) Peptides.
Madern JM, Voorneveld J, Rack JGM, Kistemaker HAV, Ahel I, van der Marel GA, Codée JDC, Filippov DV. Madern JM, et al. Among authors: ahel i. Org Lett. 2023 Jul 14;25(27):4980-4984. doi: 10.1021/acs.orglett.3c01554. Epub 2023 Jun 20. Org Lett. 2023. PMID: 37338412 Free PMC article.
Synthesis of Structural ADP-Ribose Analogues as Inhibitors for SARS-CoV-2 Macrodomain 1.
Rijpkema KJ, Schuller M, van der Veer MS, Rieken S, Chang DLR, Balić P, Todorov A, Minnee H, Wijngaarden S, Matos IA, Hoch NC, Codée JDC, Ahel I, Filippov DV. Rijpkema KJ, et al. Among authors: ahel i. Org Lett. 2024 Jul 12;26(27):5700-5704. doi: 10.1021/acs.orglett.4c01792. Epub 2024 Jun 27. Org Lett. 2024. PMID: 38935522 Free PMC article.
Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling.
Longarini EJ, Dauben H, Locatelli C, Wondisford AR, Smith R, Muench C, Kolvenbach A, Lynskey ML, Pope A, Bonfiglio JJ, Jurado EP, Fajka-Boja R, Colby T, Schuller M, Ahel I, Timinszky G, O'Sullivan RJ, Huet S, Matic I. Longarini EJ, et al. Among authors: ahel i. Mol Cell. 2023 May 18;83(10):1743-1760.e11. doi: 10.1016/j.molcel.2023.03.027. Epub 2023 Apr 27. Mol Cell. 2023. PMID: 37116497 Free PMC article.
Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.
Balıkçı E, Marques AMC, Bauer LG, Seupel R, Bennett J, Raux B, Buchan K, Simelis K, Singh U, Rogers C, Ward J, Cheng C, Szommer T, Schützenhofer K, Elkins JM, Sloman DL, Ahel I, Fedorov O, Brennan PE, Huber KVM. Balıkçı E, et al. Among authors: ahel i. J Med Chem. 2024 May 9;67(9):7245-7259. doi: 10.1021/acs.jmedchem.4c00072. Epub 2024 Apr 18. J Med Chem. 2024. PMID: 38635563 Free PMC article.
139 results