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Page 1
Optimizing the Cell Painting assay for image-based profiling.
Cimini BA, Chandrasekaran SN, Kost-Alimova M, Miller L, Goodale A, Fritchman B, Byrne P, Garg S, Jamali N, Logan DJ, Concannon JB, Lardeau CH, Mouchet E, Singh S, Shafqat Abbasi H, Aspesi P Jr, Boyd JD, Gilbert T, Gnutt D, Hariharan S, Hernandez D, Hormel G, Juhani K, Melanson M, Mervin LH, Monteverde T, Pilling JE, Skepner A, Swalley SE, Vrcic A, Weisbart E, Williams G, Yu S, Zapiec B, Carpenter AE. Cimini BA, et al. Among authors: kost alimova m. Nat Protoc. 2023 Jul;18(7):1981-2013. doi: 10.1038/s41596-023-00840-9. Epub 2023 Jun 21. Nat Protoc. 2023. PMID: 37344608 Free PMC article. Review.
Morphology and gene expression profiling provide complementary information for mapping cell state.
Way GP, Natoli T, Adeboye A, Litichevskiy L, Yang A, Lu X, Caicedo JC, Cimini BA, Karhohs K, Logan DJ, Rohban MH, Kost-Alimova M, Hartland K, Bornholdt M, Chandrasekaran SN, Haghighi M, Weisbart E, Singh S, Subramanian A, Carpenter AE. Way GP, et al. Among authors: kost alimova m. Cell Syst. 2022 Nov 16;13(11):911-923.e9. doi: 10.1016/j.cels.2022.10.001. Epub 2022 Oct 28. Cell Syst. 2022. PMID: 36395727 Free PMC article.
Discovering cellular programs of intrinsic and extrinsic drivers of metabolic traits using LipocyteProfiler.
Laber S, Strobel S, Mercader JM, Dashti H, Dos Santos FRC, Kubitz P, Jackson M, Ainbinder A, Honecker J, Agrawal S, Garborcauskas G, Stirling DR, Leong A, Figueroa K, Sinnott-Armstrong N, Kost-Alimova M, Deodato G, Harney A, Way GP, Saadat A, Harken S, Reibe-Pal S, Ebert H, Zhang Y, Calabuig-Navarro V, McGonagle E, Stefek A, Dupuis J, Cimini BA, Hauner H, Udler MS, Carpenter AE, Florez JC, Lindgren C, Jacobs SBR, Claussnitzer M. Laber S, et al. Among authors: kost alimova m. Cell Genom. 2023 Jun 20;3(7):100346. doi: 10.1016/j.xgen.2023.100346. eCollection 2023 Jul 12. Cell Genom. 2023. PMID: 37492099 Free PMC article.
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations.
Chandrasekaran SN, Cimini BA, Goodale A, Miller L, Kost-Alimova M, Jamali N, Doench JG, Fritchman B, Skepner A, Melanson M, Kalinin AA, Arevalo J, Haghighi M, Caicedo JC, Kuhn D, Hernandez D, Berstler J, Shafqat-Abbasi H, Root DE, Swalley SE, Garg S, Singh S, Carpenter AE. Chandrasekaran SN, et al. Among authors: kost alimova m. Nat Methods. 2024 Jun;21(6):1114-1121. doi: 10.1038/s41592-024-02241-6. Epub 2024 Apr 9. Nat Methods. 2024. PMID: 38594452 Free PMC article.
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.
Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, Rutter J, Therrien M, Yoon H, Lai ZW, Baublis A, Subramanian R, Devkota R, Small J, Sreekanth V, Han M, Lim D, Carpenter AE, Flannick J, Finucane H, Haigis MC, Claussnitzer M, Sheu E, Stevens B, Wagner BK, Choudhary A, Shaw JL, Pablo JL, Greka A. Wieder N, et al. Among authors: kost alimova m. bioRxiv [Preprint]. 2023 Feb 20:2023.02.19.529127. doi: 10.1101/2023.02.19.529127. bioRxiv. 2023. Update in: Cell Metab. 2023 May 2;35(5):887-905.e11. doi: 10.1016/j.cmet.2023.03.018 PMID: 36865221 Free PMC article. Updated. Preprint.
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.
Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, Rutter JC, Therrien M, Yoon H, Lai ZW, Baublis A, Subramanian R, Devkota R, Small J, Sreekanth V, Han M, Lim D, Carpenter AE, Flannick J, Finucane H, Haigis MC, Claussnitzer M, Sheu E, Stevens B, Wagner BK, Choudhary A, Shaw JL, Pablo JL, Greka A. Wieder N, et al. Among authors: kost alimova m. Cell Metab. 2023 May 2;35(5):887-905.e11. doi: 10.1016/j.cmet.2023.03.018. Epub 2023 Apr 18. Cell Metab. 2023. PMID: 37075753 Free PMC article.
nELISA: A high-throughput, high-plex platform enables quantitative profiling of the secretome.
Dagher M, Ongo G, Robichaud N, Kong J, Rho W, Teahulos I, Tavakoli A, Bovaird S, Merjaneh S, Tan A, Edwardson K, Scheepers C, Ng A, Hajjar A, Sow B, Vrouvides M, Lee A, DeCorwin-Martin P, Rasool S, Huang J, Han Y, Erps T, Coffin S, Chandrasekaran SN, Miller L, Kost-Alimova M, Skepner A, Singh S, Carpenter AE, Munzar J, Juncker D. Dagher M, et al. Among authors: kost alimova m. bioRxiv [Preprint]. 2023 Jun 28:2023.04.17.535914. doi: 10.1101/2023.04.17.535914. bioRxiv. 2023. PMID: 37131604 Free PMC article. Preprint.
Disrupted uromodulin trafficking is rescued by targeting TMED cargo receptors.
Bazua-Valenti S, Brown MR, Zavras J, Riedl Khursigara M, Grinkevich E, Sidhom EH, Keller KH, Racette M, Dvela-Levitt M, Quintanova C, Demirci H, Sewerin S, Goss AC, Lin J, Yoo H, Vaca Jacome AS, Papanastasiou M, Udeshi N, Carr SA, Himmerkus N, Bleich M, Mutig K, Bachmann S, Halbritter J, Kmoch S, Živná M, Kidd K, Bleyer AJ, Weins A, Alper SL, Shaw JL, Kost-Alimova M, Pablo JLB, Greka A. Bazua-Valenti S, et al. Among authors: kost alimova m. J Clin Invest. 2024 Dec 16;134(24):e180347. doi: 10.1172/JCI180347. J Clin Invest. 2024. PMID: 39680459 Free PMC article.
Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy.
Chaffin M, Papangeli I, Simonson B, Akkad AD, Hill MC, Arduini A, Fleming SJ, Melanson M, Hayat S, Kost-Alimova M, Atwa O, Ye J, Bedi KC Jr, Nahrendorf M, Kaushik VK, Stegmann CM, Margulies KB, Tucker NR, Ellinor PT. Chaffin M, et al. Among authors: kost alimova m. Nature. 2022 Aug;608(7921):174-180. doi: 10.1038/s41586-022-04817-8. Epub 2022 Jun 22. Nature. 2022. PMID: 35732739
76 results