Vunnam N - Search Results

1

Zafirlukast Is a Promising Scaffold for Selectively Inhibiting TNFR1 Signaling.

Vunnam N, Yang M, Lo CH, Paulson C, Fiers WD, Huber E, Been M, Ferguson DM, Sachs JN. Vunnam N, et al. ACS Bio Med Chem Au. 2023 Apr 7;3(3):270-282. doi: 10.1021/acsbiomedchemau.2c00048. eCollection 2023 Jun 21. ACS Bio Med Chem Au. 2023. PMID: 37363080 Free PMC article.

2

X-interface is not the explanation for the slow disassembly of N-cadherin dimers in the apo state.

Vunnam N, Pedigo S. Vunnam N, et al. Protein Sci. 2012 Jul;21(7):1006-14. doi: 10.1002/pro.2083. Epub 2012 May 24. Protein Sci. 2012. PMID: 22544613 Free PMC article.

3

An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors.

Lo CH, Vunnam N, Lewis AK, Chiu TL, Brummel BE, Schaaf TM, Grant BD, Bawaskar P, Thomas DD, Sachs JN. Lo CH, et al. Among authors: vunnam n. SLAS Discov. 2017 Sep;22(8):950-961. doi: 10.1177/2472555217706478. Epub 2017 May 22. SLAS Discov. 2017. PMID: 28530838 Free PMC article.

4

Death Receptor 5 Activation Is Energetically Coupled to Opening of the Transmembrane Domain Dimer.

Vunnam N, Campbell-Bezat CK, Lewis AK, Sachs JN. Vunnam N, et al. Biophys J. 2017 Jul 25;113(2):381-392. doi: 10.1016/j.bpj.2017.05.038. Biophys J. 2017. PMID: 28746849 Free PMC article.

5

Soluble Extracellular Domain of Death Receptor 5 Inhibits TRAIL-Induced Apoptosis by Disrupting Receptor-Receptor Interactions.

Vunnam N, Lo CH, Grant BD, Thomas DD, Sachs JN. Vunnam N, et al. J Mol Biol. 2017 Sep 15;429(19):2943-2953. doi: 10.1016/j.jmb.2017.08.009. Epub 2017 Aug 20. J Mol Biol. 2017. PMID: 28834692

6

Noncompetitive Allosteric Antagonism of Death Receptor 5 by a Synthetic Affibody Ligand.

Vunnam N, Szymonski S, Hirsova P, Gores GJ, Sachs JN, Hackel BJ. Vunnam N, et al. Biochemistry. 2020 Oct 13;59(40):3856-3868. doi: 10.1021/acs.biochem.0c00529. Epub 2020 Sep 30. Biochemistry. 2020. PMID: 32941010 Free PMC article.

7

Fluorescence Lifetime Measurement of Prefibrillar Sickle Hemoglobin Oligomers as a Platform for Drug Discovery in Sickle Cell Disease.

Vunnam N, Hansen S, Williams DC, Been MO, Lo CH, Pandey AK, Paulson CN, Rohde JA, Thomas DD, Sachs JN, Wood DK. Vunnam N, et al. Biomacromolecules. 2022 Sep 12;23(9):3822-3830. doi: 10.1021/acs.biomac.2c00671. Epub 2022 Aug 9. Biomacromolecules. 2022. PMID: 35944154 Free PMC article.

8

Nimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering †.

Vunnam N, Young MC, Liao EE, Lo CH, Huber E, Been M, Thomas DD, Sachs JN. Vunnam N, et al. Cancer Biol Ther. 2023 Dec 31;24(1):2176692. doi: 10.1080/15384047.2023.2176692. Cancer Biol Ther. 2023. PMID: 36775838 Free PMC article.

9

Discovery of a Non-competitive TNFR1 Antagonist Affibody with Picomolar Monovalent Potency That Does Not Affect TNFR2 Function.

Vunnam N, Been M, Huber E, Paulson C, Szymonski S, Hackel BJ, Sachs JN. Vunnam N, et al. Mol Pharm. 2023 Apr 3;20(4):1884-1897. doi: 10.1021/acs.molpharmaceut.2c00385. Epub 2023 Mar 10. Mol Pharm. 2023. PMID: 36897792 Free PMC article.

10

Indirubin Inhibits TRAIL-Induced Activation of Death Receptor 5 in Jurkat Cells.

Young MC, Vunnam N, Rebbeck RT, Yuen SL, Thomas DD, Sachs JN. Young MC, et al. Among authors: vunnam n. Nat Prod Commun. 2023 Jan;18(1):10.1177/1934578x221144580. doi: 10.1177/1934578x221144580. Epub 2023 Jan 11. Nat Prod Commun. 2023. PMID: 37063699 Free PMC article.

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