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Controlling the activation of the Bv8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals.
Maftei D, Marconi V, Florenzano F, Giancotti LA, Castelli M, Moretti S, Borsani E, Rodella LF, Balboni G, Luongo L, Maione S, Sacerdote P, Negri L, Lattanzi R. Maftei D, et al. Among authors: giancotti la. Br J Pharmacol. 2014 Nov;171(21):4850-65. doi: 10.1111/bph.12793. Epub 2014 Sep 5. Br J Pharmacol. 2014. PMID: 24902717 Free PMC article.
Inhibition of Spinal Oxidative Stress by Bergamot Polyphenolic Fraction Attenuates the Development of Morphine Induced Tolerance and Hyperalgesia in Mice.
Lauro F, Giancotti LA, Ilari S, Dagostino C, Gliozzi M, Morabito C, Malafoglia V, Raffaeli W, Muraca M, Goffredo BM, Mollace V, Muscoli C. Lauro F, et al. Among authors: giancotti la. PLoS One. 2016 May 26;11(5):e0156039. doi: 10.1371/journal.pone.0156039. eCollection 2016. PLoS One. 2016. PMID: 27227548 Free PMC article.
Exploring the Role of Bergamot Polyphenols in Alleviating Morphine-Induced Hyperalgesia and Tolerance through Modulation of Mitochondrial SIRT3.
Ilari S, Nucera S, Passacatini LC, Scarano F, Macrì R, Caminiti R, Ruga S, Serra M, Giancotti LA, Lauro F, Dagostino C, Mazza V, Ritorto G, Oppedisano F, Maiuolo J, Palma E, Malafoglia V, Tomino C, Mollace V, Muscoli C. Ilari S, et al. Among authors: giancotti la. Nutrients. 2024 Aug 9;16(16):2620. doi: 10.3390/nu16162620. Nutrients. 2024. PMID: 39203757 Free PMC article.
Continuous wound infusion of local anesthetic and steroid after major abdominal surgery: study protocol for a randomized controlled trial.
Bugada D, De Gregori M, Compagnone C, Muscoli C, Raimondi F, Bettinelli S, Avanzini MA, Cobianchi L, Peloso A, Baciarello M, Dagostino C, Giancotti LA, Ilari S, Lauro F, Grimaldi S, Tasciotti E, Fini M, Saccani Jotti GM, Meschi T, Fanelli G, Allegri M. Bugada D, et al. Among authors: giancotti la. Trials. 2015 Aug 14;16:357. doi: 10.1186/s13063-015-0874-z. Trials. 2015. PMID: 26272452 Free PMC article. Clinical Trial.
Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain.
Chen Z, Doyle TM, Luongo L, Largent-Milnes TM, Giancotti LA, Kolar G, Squillace S, Boccella S, Walker JK, Pendleton A, Spiegel S, Neumann WL, Vanderah TW, Salvemini D. Chen Z, et al. Among authors: giancotti la. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10557-10562. doi: 10.1073/pnas.1820466116. Epub 2019 May 8. Proc Natl Acad Sci U S A. 2019. PMID: 31068460 Free PMC article.
GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents.
Yosten GL, Harada CM, Haddock C, Giancotti LA, Kolar GR, Patel R, Guo C, Chen Z, Zhang J, Doyle TM, Dickenson AH, Samson WK, Salvemini D. Yosten GL, et al. Among authors: giancotti la. J Clin Invest. 2020 May 1;130(5):2587-2592. doi: 10.1172/JCI133270. J Clin Invest. 2020. PMID: 31999650 Free PMC article.
P2Y14 Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model.
Mufti F, Jung YH, Giancotti LA, Yu J, Chen Z, Phung NB, Jacobson KA, Salvemini D. Mufti F, et al. Among authors: giancotti la. ACS Med Chem Lett. 2020 Apr 30;11(6):1281-1286. doi: 10.1021/acsmedchemlett.0c00115. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32551012 Free PMC article.
25 results