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Structural and functional studies of the EGF20-27 region reveal new features of the human Notch receptor important for optimal activation.
Bo Z, Rowntree T, Johnson S, Nurmahdi H, Suckling RJ, Hill J, Korona B, Weisshuhn PC, Sheppard D, Meng Y, Liang S, Lowe ED, Lea SM, Redfield C, Handford PA. Bo Z, et al. Among authors: lea sm. Structure. 2024 Dec 5;32(12):2325-2336.e5. doi: 10.1016/j.str.2024.10.012. Epub 2024 Nov 1. Structure. 2024. PMID: 39488203 Free article.
Structural basis for antibiotic transport and inhibition in PepT2.
Parker JL, Deme JC, Lichtinger SM, Kuteyi G, Biggin PC, Lea SM, Newstead S. Parker JL, et al. Among authors: lea sm. Nat Commun. 2024 Oct 9;15(1):8755. doi: 10.1038/s41467-024-53096-6. Nat Commun. 2024. PMID: 39384780 Free PMC article.
Structural basis of directional switching by the bacterial flagellum.
Johnson S, Deme JC, Furlong EJ, Caesar JJE, Chevance FFV, Hughes KT, Lea SM. Johnson S, et al. Among authors: lea sm. Nat Microbiol. 2024 May;9(5):1282-1292. doi: 10.1038/s41564-024-01630-z. Epub 2024 Mar 8. Nat Microbiol. 2024. PMID: 38459206
A type VII-secreted lipase toxin with reverse domain arrangement.
Garrett SR, Mietrach N, Deme J, Bitzer A, Yang Y, Ulhuq FR, Kretschmer D, Heilbronner S, Smith TK, Lea SM, Palmer T. Garrett SR, et al. Among authors: lea sm. Nat Commun. 2023 Dec 19;14(1):8438. doi: 10.1038/s41467-023-44221-y. Nat Commun. 2023. PMID: 38114483 Free PMC article.
Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40.
Alteen MG, Deme JC, Alvarez CP, Loppnau P, Hutchinson A, Seitova A, Chandrasekaran R, Silva Ramos E, Secker C, Alqazzaz M, Wanker EE, Lea SM, Arrowsmith CH, Harding RJ. Alteen MG, et al. Among authors: lea sm. Structure. 2023 Sep 7;31(9):1121-1131.e6. doi: 10.1016/j.str.2023.06.002. Epub 2023 Jun 29. Structure. 2023. PMID: 37390814 Free PMC article.
Delivering a toxic metal to the active site of urease.
Nim YS, Fong IYH, Deme J, Tsang KL, Caesar J, Johnson S, Pang LTH, Yuen NMH, Ng TLC, Choi T, Wong YYH, Lea SM, Wong KB. Nim YS, et al. Among authors: lea sm. Sci Adv. 2023 Apr 21;9(16):eadf7790. doi: 10.1126/sciadv.adf7790. Epub 2023 Apr 21. Sci Adv. 2023. PMID: 37083535 Free PMC article.
153 results