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Milking the Cow: Cattle-Derived Chimeric Ultralong CDR-H3 Antibodies and Their Engineered CDR-H3-Only Knobbody Counterparts Targeting Epidermal Growth Factor Receptor Elicit Potent NK Cell-Mediated Cytotoxicity.
Pekar L, Klewinghaus D, Arras P, Carrara SC, Harwardt J, Krah S, Yanakieva D, Toleikis L, Smider VV, Kolmar H, Zielonka S. Pekar L, et al. Among authors: arras p. Front Immunol. 2021 Oct 25;12:742418. doi: 10.3389/fimmu.2021.742418. eCollection 2021. Front Immunol. 2021. PMID: 34759924 Free PMC article.
Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition.
Lipinski B, Unmuth L, Arras P, Becker S, Bauer C, Toleikis L, Krah S, Doerner A, Yanakieva D, Boje AS, Klausz K, Peipp M, Siegmund V, Evers A, Kolmar H, Pekar L, Zielonka S. Lipinski B, et al. Among authors: arras p. MAbs. 2023 Jan-Dec;15(1):2236265. doi: 10.1080/19420862.2023.2236265. MAbs. 2023. PMID: 37469014 Free PMC article.
AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of de novo humanized and sequence-optimized single domain antibodies: a prospective case study.
Arras P, Yoo HB, Pekar L, Clarke T, Friedrich L, Schröter C, Schanz J, Tonillo J, Siegmund V, Doerner A, Krah S, Guarnera E, Zielonka S, Evers A. Arras P, et al. Front Mol Biosci. 2023 Sep 28;10:1249247. doi: 10.3389/fmolb.2023.1249247. eCollection 2023. Front Mol Biosci. 2023. PMID: 37842638 Free PMC article.
Bovine ultralong CDR-H3 derived knob paratopes elicit potent TNF-α neutralization and enable the generation of novel adalimumab-based antibody architectures with augmented features.
Arras P, Zimmermann J, Lipinski B, Valldorf B, Evers A, Elter D, Krah S, Doerner A, Guarnera E, Siegmund V, Kolmar H, Pekar L, Zielonka S. Arras P, et al. Biol Chem. 2024 Feb 20;405(7-8):461-470. doi: 10.1515/hsz-2023-0370. Print 2024 Jul 26. Biol Chem. 2024. PMID: 38373142 Free article.
19 results